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GPCR

NameFree fatty acid receptor 1
SpeciesRattus norvegicus (Rat)
GeneFfar1
SynonymFFA1 receptor
FFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
DiseaseN/A for non-human GPCRs
Length300
Amino acid sequenceMDLPPQLSFALYVSAFALGFPLNLLAIRGAVSHAKLRLTPSLVYTLHLACSDLLLAITLPLKAVEALASGVWPLPLPFCPVFALAHFAPLYAGGGFLAALSAGRYLGAAFPFGYQAIRRPCYSWGVCVAIWALVLCHLGLALGLEAPRGWVDNTTSSLGINIPVNGSPVCLEAWDPDSARPARLSFSILLFFLPLVITAFCYVGCLRALVHSGLSHKRKLRAAWVAGGALLTLLLCLGPYNASNVASFINPDLEGSWRKLGLITGAWSVVLNPLVTGYLGTGPGQGTICVTRTPRGTIQK
UniProtQ8K3T4
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1795180
IUPHARN/A
DrugBankN/A

Ligand

NameSCHEMBL17418947
Molecular formulaC30H32FN3O4
IUPAC name(3S)-3-cyclopropyl-3-[3-[[6-(5,5-dimethylcyclopenten-1-yl)-5-(5-fluoro-2-methoxypyridin-4-yl)pyrazin-2-yl]methoxy]phenyl]propanoic acid
Molecular weight517.601
Hydrogen bond acceptor8
Hydrogen bond donor1
XlogP5.0
SynonymsUS9688642, 15
BDBM168184
US9688642, 30
Inchi KeyNEANWAJDBGJJSW-QFIPXVFZSA-N
Inchi IDInChI=1S/C30H32FN3O4/c1-30(2)11-5-8-24(30)29-28(23-13-26(37-3)32-16-25(23)31)33-15-20(34-29)17-38-21-7-4-6-19(12-21)22(14-27(35)36)18-9-10-18/h4,6-8,12-13,15-16,18,22H,5,9-11,14,17H2,1-3H3,(H,35,36)/t22-/m0/s1
PubChem CID118645715
ChEMBLN/A
IUPHARN/A
BindingDB168184
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC5018.0 nMN/ABindingDB
EC50201.0 nMN/ABindingDB

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