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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	G-protein coupled bile acid receptor 1
Species	Homo sapiens (Human)
Gene	GPBAR1
Synonym	G-protein coupled receptor GPCR19 TGR5 BG37 G protein-coupled bile acid receptor 1 membrane-type receptor for bile acids M-BAR hGPCR19 hBG37 GPCR19 GPBAR1 GPBA receptor GPR131 [ Show all ]
Disease	Type 2 diabetes Metabolic disorders
Length	330
Amino acid sequence	MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQPPGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGAAAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPYVATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQGLWGRASRDSPGPSIAYHPSSQSSVDLDLN
UniProt	Q8TDU6
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDU6
3D structure model	This predicted structure model is from GPCR-EXP Q8TDU6.
BioLiP	N/A
Therapeutic Target Database	T86273
ChEMBL	CHEMBL5409
IUPHAR	37
DrugBank	BE0005788

Ligand

Name	SCHEMBL364053
Molecular formula	C23H25N3O
IUPAC name	(NE)-N-[3-[4-(dimethylamino)phenyl]-3-(4-methylphenyl)-1-pyridin-4-ylpropylidene]hydroxylamine
Molecular weight	359.473
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	4.6
Synonyms	N/A
Inchi Key	MHMBXAPAZTZTON-WJTDDFOZSA-N
Inchi ID	InChI=1S/C23H25N3O/c1-17-4-6-18(7-5-17)22(19-8-10-21(11-9-19)26(2)3)16-23(25-27)20-12-14-24-15-13-20/h4-15,22,27H,16H2,1-3H3/b25-23+
PubChem CID	136239453
ChEMBL	CHEMBL2407946
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	100.0 nM	PMID23831134	ChEMBL
Efficacy	155.0 %	PMID23831134	ChEMBL

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