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GPCR

NameFree fatty acid receptor 1
SpeciesHomo sapiens (Human)
GeneFFAR1
SynonymFFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
FFA1 receptor
DiseaseType 2 diabetes
Non-insulin dependent diabetes
Diabetes
Length300
Amino acid sequenceMDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProtO14842
Protein Data Bank5tzy, 5tzr
GPCR-HGmod modelO14842
3D structure modelThis structure is from PDB ID 5tzy.
BioLiPBL0380462, BL0380463, BL0380464
Therapeutic Target DatabaseT25608
ChEMBLCHEMBL4422
IUPHAR225
DrugBankBE0000688

Ligand

NameSCHEMBL17419073
Molecular formulaC27H30FN3O5
IUPAC name(3S)-3-cyclopropyl-3-[3-[[5-(5-fluoro-2-methoxypyridin-4-yl)-6-(2-methylpropoxy)pyrazin-2-yl]methoxy]phenyl]propanoic acid
Molecular weight495.551
Hydrogen bond acceptor9
Hydrogen bond donor1
XlogP4.6
SynonymsUS9688642, 12
BDBM168159
Inchi KeyJVHQJROTKODAGV-NRFANRHFSA-N
Inchi IDInChI=1S/C27H30FN3O5/c1-16(2)14-36-27-26(22-10-24(34-3)29-13-23(22)28)30-12-19(31-27)15-35-20-6-4-5-18(9-20)21(11-25(32)33)17-7-8-17/h4-6,9-10,12-13,16-17,21H,7-8,11,14-15H2,1-3H3,(H,32,33)/t21-/m0/s1
PubChem CID118645821
ChEMBLN/A
IUPHARN/A
BindingDB168159
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5010.0 nMN/ABindingDB

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