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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Apelin receptor
Species	Homo sapiens (Human)
Gene	APLNR
Synonym	msr/apj GPCR34 G-protein coupled receptor HG11 G-protein coupled receptor APJ AGTRL1 angiotensin II receptor-like 1 angiotensin receptor-like 1 APJR APJ apelin receptor B78 [ Show all ]
Disease	N/A
Length	380
Amino acid sequence	MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
UniProt	P35414
Protein Data Bank	5vbl
GPCR-HGmod model	P35414
3D structure model	This structure is from PDB ID 5vbl.
BioLiP	BL0380094, BL0380093
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1628481
IUPHAR	36
DrugBank	N/A

Ligand

Name	(4,6-diphenylpyrimidin-2-yl)hydrazine
Molecular formula	C16H14N4
IUPAC name	(4,6-diphenylpyrimidin-2-yl)hydrazine
Molecular weight	262.316
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	3.1
Synonyms	MCULE-8342616212 4,6-diphenylpyrimidin-2-ylhydrazine CTK7F1728 SCHEMBL2401750 (4,6-diphenyl-2-pyrimidinyl)hydrazine AC1M49QR HMS1394O14 BDBM67270 CHEMBL1375248 MLS000856324 5588-58-9 DTXSID40367886 SMR000279269 (4,6-Diphenyl-pyrimidin-2-yl)-hydrazine AKOS001016733 HMS2686O04 2-HYDRAZINO-4,6-DIPHENYL-PYRIMIDINE CBDivE_006945 cid_2303647 MolPort-001-915-228 Enamine_000322 ZINC3091431 (4,6-diphenylpyrimidin-2-yl)diazane BAS 00117023 [ Show all ]
Inchi Key	DBYCDKBEVKWZNL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H14N4/c17-20-16-18-14(12-7-3-1-4-8-12)11-15(19-16)13-9-5-2-6-10-13/h1-11H,17H2,(H,18,19,20)
PubChem CID	2303647
ChEMBL	CHEMBL1375248
IUPHAR	N/A
BindingDB	67270
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	6790.0 nM	N/A	BindingDB

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