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GPCR

NameFree fatty acid receptor 1
SpeciesHomo sapiens (Human)
GeneFFAR1
SynonymFFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
FFA1 receptor
DiseaseType 2 diabetes
Non-insulin dependent diabetes
Diabetes
Length300
Amino acid sequenceMDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProtO14842
Protein Data Bank5tzy, 5tzr
GPCR-HGmod modelO14842
3D structure modelThis structure is from PDB ID 5tzy.
BioLiPBL0380462, BL0380463, BL0380464
Therapeutic Target DatabaseT25608
ChEMBLCHEMBL4422
IUPHAR225
DrugBankBE0000688

Ligand

NameSCHEMBL17418823
Molecular formulaC27H27FN2O6
IUPAC name(3S)-3-cyclopropyl-3-[3-[[5-(2-fluoro-5-methoxyphenyl)-6-(oxetan-3-yloxy)pyrazin-2-yl]methoxy]phenyl]propanoic acid
Molecular weight494.519
Hydrogen bond acceptor9
Hydrogen bond donor1
XlogP3.7
SynonymsUS9688642, 41
BDBM168192
Inchi KeyFXGAMSDSYFEUTK-QFIPXVFZSA-N
Inchi IDInChI=1S/C27H27FN2O6/c1-33-19-7-8-24(28)23(10-19)26-27(36-21-14-34-15-21)30-18(12-29-26)13-35-20-4-2-3-17(9-20)22(11-25(31)32)16-5-6-16/h2-4,7-10,12,16,21-22H,5-6,11,13-15H2,1H3,(H,31,32)/t22-/m0/s1
PubChem CID118645601
ChEMBLN/A
IUPHARN/A
BindingDB168192
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5074.0 nMN/ABindingDB

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