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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Platelet-activating factor receptor
Species	Rattus norvegicus (Rat)
Gene	Ptafr
Synonym	AGEPC receptor PAF receptor PAF-R PAFr
Disease	N/A for non-human GPCRs
Length	341
Amino acid sequence	MEQNGSFRVDSEFRYTLFPIVYSVIFVLGVVANGYVLWVFATLYPSKKLNEIKIFMVNLTVADLLFLMTLPLWIVYYSNEGDWIVHKFLCNLAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGITLSLVIWISIAATASYFLATDSTNVVPKKDGSGNITRCFEHYEPYSVPILVVHIFITSCFFLVFFLIFYCNMVIIHTLLTRPVRQQRKPEVKRRALWMVCTVLAVFVICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVMMPANQTPVLPLKN
UniProt	P46002
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4127
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL340544
Molecular formula	C26H25N3O
IUPAC name	2-[1-(2,2-diphenylacetyl)piperidin-4-yl]-2-pyridin-3-ylacetonitrile
Molecular weight	395.506
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	4.1
Synonyms	BDBM50003536 SCHEMBL9852966 2-[1-(1-Oxo-2,2-diphenylethyl)-4-piperidinyl]-2-(3-pyridinyl)acetonitrile (1-Diphenylacetyl-piperidin-4-yl)-pyridin-3-yl-acetonitrile
Inchi Key	DBKJBAQPDMQAHQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H25N3O/c27-18-24(23-12-7-15-28-19-23)20-13-16-29(17-14-20)26(30)25(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-12,15,19-20,24-25H,13-14,16-17H2
PubChem CID	10408388
ChEMBL	CHEMBL340544
IUPHAR	N/A
BindingDB	50003536
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
ID50	0.023 mg.kg-1	PMID1433215	ChEMBL

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