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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Rattus norvegicus (Rat)
Gene	Htr4
Synonym	5-HT-4 5-HT4 5-HT4 receptor 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled serotonin receptor 4
Disease	N/A for non-human GPCRs
Length	406
Amino acid sequence	MDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS
UniProt	Q62758
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4317
IUPHAR	9
DrugBank	N/A

Ligand

Name	1H-Indol-5-ol, 3-(2-aminoethyl)-1-methyl-
Molecular formula	C11H14N2O
IUPAC name	3-(2-aminoethyl)-1-methylindol-5-ol
Molecular weight	190.246
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	1.0
Synonyms	CTK0I7743 3-(2-aminoethyl)-1-methylindol-5-ol PDSP1_000783 AC1L9A8V ZINC896081 DTXSID80331546 5-HT,a-Me PDSP2_000771 BDBM81781 2380-88-3 MCULE-8843854858 SCHEMBL658829 [ Show all ]
Inchi Key	RLDFVSFNVOLFEU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H14N2O/c1-13-7-8(4-5-12)10-6-9(14)2-3-11(10)13/h2-3,6-7,14H,4-5,12H2,1H3
PubChem CID	440945
ChEMBL	N/A
IUPHAR	N/A
BindingDB	81781
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	263.0 nM	PMID8813606	BindingDB
Ki	398.1 nM	PMID9225293	BindingDB
Ki	1450.0 nM	PMID7796807, PMID8813606	BindingDB
Ki	2511.88 nM	PMID9225293	BindingDB
Ki	5011.87 nM	PMID9225293	BindingDB

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