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GLASS

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GPCR

Name	Leukotriene B4 receptor 2
Species	Homo sapiens (Human)
Gene	LTB4R2
Synonym	NOP9 12-HHT receptor Seven transmembrane receptor BLTR2 LTB4-R2 LTB4-R 2 LTB4 receptor JULF2 Leukotriene B4 receptor BLT2 BLTR2 BLT2 receptor [ Show all ]
Disease	Inflammatory bowel disease
Length	358
Amino acid sequence	MSVCYRPPGNETLLSWKTSRATGTAFLLLAALLGLPGNGFVVWSLAGWRPARGRPLAATLVLHLALADGAVLLLTPLFVAFLTRQAWPLGQAGCKAVYYVCALSMYASVLLTGLLSLQRCLAVTRPFLAPRLRSPALARRLLLAVWLAALLLAVPAAVYRHLWRDRVCQLCHPSPVHAAAHLSLETLTAFVLPFGLMLGCYSVTLARLRGARWGSGRHGARVGRLVSAIVLAFGLLWAPYHAVNLLQAVAALAPPEGALAKLGGAGQAARAGTTALAFFSSSVNPVLYVFTAGDLLPRAGPRFLTRLFEGSGEARGGGRSREGTMELRTTPQLKVVGQGRGNGDPGGGMEKDGPEWDL
UniProt	Q9NPC1
Protein Data Bank	N/A
GPCR-HGmod model	Q9NPC1
3D structure model	This predicted structure model is from GPCR-EXP Q9NPC1.
BioLiP	N/A
Therapeutic Target Database	T30563
ChEMBL	CHEMBL3191
IUPHAR	268
DrugBank	BE0003489

Ligand

Name	CHEMBL53132
Molecular formula	C18H26N4O3
IUPAC name	1-[5-ethyl-2-hydroxy-4-[5-methyl-5-(2H-tetrazol-5-yl)hexoxy]phenyl]ethanone
Molecular weight	346.431
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	4.1
Synonyms	BDBM81518 4'-[5-Methyl-5-(1H-tetrazol-5-yl)hexyloxy]-5'-ethyl-2'-hydroxyacetophenone CGS 23167
Inchi Key	RHHDWFGUSMVSMD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H26N4O3/c1-5-13-10-14(12(2)23)15(24)11-16(13)25-9-7-6-8-18(3,4)17-19-21-22-20-17/h10-11,24H,5-9H2,1-4H3,(H,19,20,21,22)
PubChem CID	15747304
ChEMBL	CHEMBL53132
IUPHAR	N/A
BindingDB	81518
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	293.0 nM	PMID1320692	BindingDB
Ki	364.0 nM	PMID1320692	BindingDB

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