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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Rattus norvegicus (Rat)
Gene	Htr2a
Synonym	serotonin 5HT-2 receptor 5Ht-2 'D' receptor 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 5-HT2A receptor 5-HT-2A 5-HT-2 serotonin receptor 2A [ Show all ]
Disease	N/A for non-human GPCRs
Length	471
Amino acid sequence	MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
UniProt	P14842
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL322
IUPHAR	6
DrugBank	N/A

Ligand

Name	5-Bromotryptamine
Molecular formula	C10H11BrN2
IUPAC name	2-(5-bromo-1H-indol-3-yl)ethanamine
Molecular weight	239.116
Hydrogen bond acceptor	1
Hydrogen bond donor	2
XlogP	1.3
Synonyms	CTK4H5898 ZINC403685 1613AE 5-Br-T ACN-049131 BDBM50331288 K-8096 2-(5-BROMO-1H-INDOL-3-YL)-ETHYLAMINE Oprea1_552997 3-(2-Aminoethyl)-5-bromoindole AC1L2SH6 EINECS 222-779-8 1H-INDOLE-3-ETHANAMINE, 5-BROMO- 5-Bromo-1H-indole-3-ethylamine AJ-22171 BP-13334 KB-244764 2-(5-BROMO-1H-INDOL-3-YL)ETHAN-1-AMINE CHEMBL1288717 SCHEMBL1520598 3610-42-2 AC1Q25YL F2113-0573 1H-Indole-3-ethanamine,5-bromo- 5-bromo-tryptamine AKOS005207534 CGHUQJRRADEHTQ-UHFFFAOYSA-N MFCD00130169 2-(5-bromo-1H-indol-3-yl)ethanamine AB03690 [ Show all ]
Inchi Key	CGHUQJRRADEHTQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H11BrN2/c11-8-1-2-10-9(5-8)7(3-4-12)6-13-10/h1-2,5-6,13H,3-4,12H2
PubChem CID	77158
ChEMBL	CHEMBL1288717
IUPHAR	N/A
BindingDB	50331288
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	3245.0 nM	PMID8510008	BindingDB

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