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GPCR

Name	5-hydroxytryptamine receptor 7
Species	Rattus norvegicus (Rat)
Gene	Htr7
Synonym	GPRFO 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 5-HTx 5-HT7 receptor 5-HT7 5-HT1Y 5-HT-X 5-HT-7 Serotonin receptor 7 [ Show all ]
Disease	N/A for non-human GPCRs
Length	448
Amino acid sequence	MMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNSDHCGKKGHDT
UniProt	P32305
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3223
IUPHAR	12
DrugBank	N/A

Ligand

Name	propranolol
Molecular formula	C16H21NO2
IUPAC name	1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol
Molecular weight	259.349
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	3.0
Synonyms	AQHHHDLHHXJYJD-UHFFFAOYSA-N KBioGR_001684 BBL023437 NCGC00024690-02 LS-184129 Betadren Oprea1_304193 BSPBio_000944 Prestwick0_000952 (A+/-)-Propranolol hydrochloride CHEBI:8499 PROPANOLOL(-) 1-(alpha-naphthoxy)-3-(iso-propylamino)-2-propanol PROPRANOLOL, d 1-Isopropylamino-3-(1-naphthyloxy)-2-propanol Efektolol R,S-Propranolol Hydrochloride 2-Propanol, 1-(isopropylamino)-3-(1-naphthyloxy)- FT-0700657 SCHEMBL3955 Inderal (Salt/Mix) Spectrum3_001071 AC1Q1QC0 KBio1_000023 W-109550 KBio2_007651 Avlocardyl (Salt/Mix) Kemi S Berkolol NSC 91523 (Salt/Mix) MolPort-001-794-623 Bio1_000856 PDSP1_001608 C16H21NO2 Prestwick3_000952 .beta.-Propranolol cMAP_000071 1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol dl-propranolol propranololo 13013-17-7 EN300-40731 Reducor HMS2090L21 SPBio_001658 AB00053537_11 INDERIDE-40/25 Spectrum5_000751 ALBB-023324 KBio3_002993 AY-20694 NCGC00015798-08 Lopac0_000896 Beta-Timelets Obsidan (Salt/Mix) NCGC00015798-06 BRD-A10070317-003-06-9 PDSP2_001592 (.+/-.)-Propranolol CCG-103643 Propanolol 1-((1-Methylethyl)amino)-3-(1-naphthyloxy)-2-propanol D,L-Propranolol Propranolol Hcl Intensol 1-(isopropylamino)-3-naphthalen-1-yloxy-propan-2-ol Dociton (Salt/Mix) Propranololum [INN-Latin] 2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-, (+-)- F0001-3681 SBI-0050871.P003 525-66-6 IDI1_000023 Spectrum2_001699 AC1L1JA4 Intermigran Sumial Anaprilin [2-hydroxy-3-(naphthalen-1-yloxy)propyl](propan-2-yl)amine ARONIS27011 KBioGR_002515 BDBM25761 NCGC00024690-03 MCULE-7804628650 Betalong PDSP1_000767 BSPBio_002682 Prestwick1_000952 (S)-(-)-PROPRANOLOL Propanolol,(+/-) 1-(alpha-naphthoxy)-3-(isopropylamino)-2-propanol DB00571 PROPRANOLOL,(+) 1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol EINECS 208-378-0 Racemic propranolol 2-Propanol, 1-(isopropylamino)-3-(1-naphthyloxy)-, (+-)- GTPL564 Servanolol AB00053537 Inderal hydrochloride Spectrum4_000974 AKOS000588816 KBio2_002515 KBio3_001766 AY 20694 KS-00002WT3 beta-Propranolol NSC91523 NCGC00015798-04 Bio1_001345 PDSP2_000755 (+-)-Propranolol Caridolol Propanalol 1(-alpha-naphthoxy)-3-(iso-propylamino)-2-propanol Corpendol Propranolol (INN) 1-(isopropylamino)-3-(1-naphthyloxy)propan-2-ol DL-Propranolol hydrochloride Propranololo [DCIT] 2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)- etalong Reducor line 3-(naphthalen-1-yloxy)-1-(propan-2-ylamino)propan-2-ol HMS3428G03 SPBio_003093 AB00053537_12 INDERIDE-80/25 ST024757 AN-18866 Anapriline KBioGR_001347 b-Propranolol NCGC00015798-09 LS-122410 Betachron Obzidan BRD-A10070317-003-17-6 Pranolol (1)-1-(Isopropylamino)-3-(naphthyloxy)propan-2-ol CCRIS 3082 Propanolol [INN-Spanish] 1-(1-Naphthyloxy)-2-hydroxy-3-(isopropylamino)propane D08443 Propranolol [INN:BAN] 1-(naphthalen-1-yloxy)-3-(propan-2-ylamino)propan-2-ol DTXSID6023525 Proprasylyt 2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-, (+-)- (9CI) FE-0204 SCHEMBL12264958 525P666 Inderal Spectrum3_000883 AC1Q1QBV KB-123971 T7896 Avlocardyl KBioSS_002523 Bedranol NINDS_000023 Migrastat Bio1_000367 PDSP1_001607 C07407 Prestwick2_000952 CHEMBL27 Propranalol 1-(Isopropylamino)-3-(1-naphthoxy)-propan-2-ol DivK1c_000023 PROPRANOLOL,(-) 1-[(1-methylethyl)amino]-3-(naphthalen-1-yloxy)propan-2-ol EINECS 235-867-6 racemic-Propranolol 2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)- hemangiol SPBio_001361 AB00053537-10 Inderex Spectrum4_001222 AKOS016050338 KBio2_005083 KBio3_001902 AY 64043 NCGC00015798-07 L000679 Beta-Tablinen Obsidan NCGC00015798-05 BPBio1_001040 PDSP2_001591 (+/-)-Propranolol-D7 (ring-D7) solution, 100 mug/mL in methanol with 5% 1 M HCl, ampule of 1 mL, certified reference material CBDivE_006180 Propanix 1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol CTK8I6896 Propranolol (TN) 1-(Isopropylamino)-3-(naphthalen-1-yloxy)propan-2-ol Dociton Propranololum 2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)- (9CI) Euprovasin Sawatal 3-[(methylethyl)amino]-1-naphthyloxypropan-2-ol ICI 45520 (Salt/Mix) Spectrum2_001301 AB0108847 Inderol STK735510 AN-45556 [ Show all ]
Inchi Key	AQHHHDLHHXJYJD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3
PubChem CID	4946
ChEMBL	CHEMBL27
IUPHAR	564
BindingDB	25761
DrugBank	DB00571
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	5000.0 nM	PMID7724	BindingDB
Ki	7000.0 nM	PMID7724	BindingDB

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