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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Rattus norvegicus (Rat)
Gene	Htr2a
Synonym	serotonin 5HT-2 receptor 5Ht-2 'D' receptor 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 5-HT2A receptor 5-HT-2A 5-HT-2 serotonin receptor 2A [ Show all ]
Disease	N/A for non-human GPCRs
Length	471
Amino acid sequence	MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
UniProt	P14842
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL322
IUPHAR	6
DrugBank	N/A

Ligand

Name	chlorpromazine
Molecular formula	C17H19ClN2S
IUPAC name	3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine
Molecular weight	318.863
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	5.2
Synonyms	Thorazine (TN) KSC-315-032- NCGC00015273-08 Chlordelazine U42B7VYA4P (chlorpromazine)[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine NCGC00015273-16 [3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine 2-Chloro-10-(3-dimethylaminopropyl)phenothiazine NINDS_000624 Chlorpromazinum [INN-Latin] 2601A NSC17479 CTK1C5154 4560 R.P. Phenothiazine, 2-chloro-10-[3-(dimethylamino)propyl]- DSSTox_RID_76736 AB00051943_17 Proma Fraction AB Aminazine QSPL 401 HMS2091E06 Largactil BBL028251 SKF 2601-A KB-232587 Lopac0_000249 BPBio1_000273 Spectrum3_000346 KBio3_001231 N-(3-Dimethylaminopropyl)-3-chlorophenothiazine CAS-69-09-0 CHEBI:3647 Thorazine Suppositories NCGC00015273-11 Chloro-3 (dimethylamino-3 propyl)-10 phenothiazine [French] Wintermin 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl- NCGC00024409-04 Chlorpromazine Tannate [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine (chlor-promazine) 2-chloro-N,N-dimethyl-10H-Phenothiazine-10-propanamine Novomazina Clorpromazina [Italian] 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine Pharmakon1600-01500184 Prazilpromactil Elmarin AC1L1EBT Promazil GTPL83 Amplictil RP-4560 HSDB 3033 Largactil Oral Drops BDBM50001888 SMR001453710 KBio2_002312 M176 BSPBio_000247 Spectrum_000142 KBioGR_002312 NCGC00015273-03 KS-00002WW5 NCGC00015273-06 Chlor-Promanyl Tox21_110120_1 NCGC00015273-14 Chlorpromanyl (discontinued) ZINC44027 2-chloro-10-(3-(dimethylamino)propyl)-phenothiazine NCGC00024409-07 Chlorpromazine;[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine 2-Cloro-10 (3-dimetilaminopropil)fenotiazina [Italian] NSC-756689 CPZ 34468-21-8 Phenothiazine hydrochloride DSSTox_CID_2808 AB00051943-15 Prestwick2_000064 Fenactil Aminasine Prozil HMS1920M03 AX8120990 SC-50091 J10069 Lomazine (Salt/Mix) Bio1_001435 SPECTRUM1500184 KBio2_005758 MLS003166901 C17H19ClN2S STK182870 Thorazine hydrochloride KUC112482N NCGC00015273-09 Chlorderazin UNII-U42B7VYA4P NCGC00015273-17 Chlorpromazine (USP/INN) [3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine hydrochloride 2-chloro-10-[3-(dimethylamino)propyl]- Norcozine (Salt/Mix) Clorpromazina 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine NSC756689 D00270 4560 Rp hydrochloride Plegomasine DTXSID0022808 AB00051943_18 Promactil FT-0653683 Ampliactil QTL1_000021 HMS3430C19 Largactil (TN) BC 135 SKF 2601A KBio1_000624 LS-105361 BPBio1_001181 Spectrum4_000283 KBio3_002792 NCGC00015273-01 CCG-40059 NCGC00015273-04 Torazina NCGC00015273-12 Chloropromazine WLN: T C666 BN ISJ B3N1&1 EG 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-, radical ion(1+) NCGC00024409-05 Chlorpromazine [USAN:INN:BAN] [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine( Chlorpromazine) 2-Chloropromazine NSC 167745 cMAP_000017 3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine Phenactyl DB00477 Prestwick0_000064 Epitope ID:136898 AKOS001490972 Propaphen Hibernal (Salt/Mix) AN-41563 Sanopron I14-6226 Largactilothiazine Bio1_000457 SPBio_001111 KBio2_003190 MCULE-5976054678 BSPBio_002011 SR-01000000012-5 KBioSS_000622 KS-5101 NCGC00015273-07 Chlor-PZ Tranzine (Salt/Mix) (chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine NCGC00015273-15 Chlorpromazin ZPEIMTDSQAKGNT-UHFFFAOYSA-N 2-Chloro-10-(3-(dimethylamino)propyl)phenothiazine NCGC00024409-08 Chlorpromazinum 2601-A NSC167745 Cromedazine 4560 R.P Phenothiazine, 2-chloro-10-(3-(dimethylamino)propyl)- DSSTox_GSID_22808 AB00051943-16 Prestwick3_000064 Fenaktyl Aminazin Psychozine HMS2089C12 L000182 BAS 00010434 SCHEMBL8321 JHICC02042 Lopac-C-8138 Biomol-NT_000020 Spectrum2_001156 KBio2_007448 MolPort-001-727-953 CAS-50-53-3 Thorazine CCRIS 3711 Thorazine Spansule NCGC00015273-10 Chloro-3 (dimethylamino-3 propyl)-10 phenothiazine Unitensen 10-(3-Dimethylaminopropyl)-2-chlorophenothiazine NCGC00015273-19 Chlorpromazine cation radical [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine 2-Chloro-10-[3-(dimethylamino)propyl]phenothiazine Novo-Chlorpromazine Clorpromazina [INN-Spanish] 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine # Oprea1_110255 D01ZII 50-53-3 Plegomazin EINECS 200-045-8 AB0015094 Promapar GG 407 Amplicitil R1242 HMS501P06 Largactil Liquid BCP03610 SKF-2601 KBio2_000622 M-1209 BRD-K89997465-001-05-3 Spectrum5_000717 KBioGR_000806 NCGC00015273-02 NCGC00015273-05 CHEMBL71 Tox21_110120 NCGC00015273-13 Chlorpromados Z80 1N,1N-dimethyl-3-(2-chloro-10H-10-phenothiazinyl)-1-propanamine NCGC00024409-06 Chlorpromazine [USP:INN:BAN] [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine(clorpromazine) 2-Cloro-10 (3-dimetilaminopropil)fenotiazina NSC-167745 Contomin 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine Phenathyl DivK1c_000624 AB00051943 Prestwick1_000064 Esmind ALBB-022464 Propaphenin HL 5746 API0001970 SBI-0050237.P004 IDI1_000624 Largactyl Bio1_000946 SPBio_002168 KBio2_004880 Megaphen C06906 SR-01000000012-6 KBioSS_002314 [ Show all ]
Inchi Key	ZPEIMTDSQAKGNT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
PubChem CID	2726
ChEMBL	CHEMBL71
IUPHAR	83
BindingDB	50001888
DrugBank	DB00477
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1.99526 nM	PMID9655845	IUPHAR
Ki	2.0 nM	PMID1347569, PMID8524985	BindingDB
Ki	2.51 nM	PMID7908055	BindingDB
Ki	3.01 nM	PMID7984267	BindingDB
Ki	3.6 nM	PMID9686407	BindingDB
Ki	7.94 nM	PMID7984267	BindingDB
Ki	11.0 nM	PMID2795135	BindingDB
Ki	31.0 nM	PMID2869639	BindingDB

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