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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Rattus norvegicus (Rat)
Gene	Htr2a
Synonym	serotonin 5HT-2 receptor 5Ht-2 'D' receptor 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 5-HT2A receptor 5-HT-2A 5-HT-2 serotonin receptor 2A [ Show all ]
Disease	N/A for non-human GPCRs
Length	471
Amino acid sequence	MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
UniProt	P14842
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL322
IUPHAR	6
DrugBank	N/A

Ligand

Name	chlorpromazine
Molecular formula	C17H19ClN2S
IUPAC name	3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine
Molecular weight	318.863
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	5.2
Synonyms	KBio2_000622 MLS003166901 BRD-K89997465-001-05-3 STK182870 KBioGR_000806 NCGC00015273-06 CCRIS 3711 Tox21_110120_1 NCGC00015273-14 Chloro-3 (dimethylamino-3 propyl)-10 phenothiazine ZINC44027 10-(3-Dimethylaminopropyl)-2-chlorophenothiazine NCGC00024409-07 Chlorpromazine cation radical 2-Chloro-10-[3-(dimethylamino)propyl]phenothiazine NSC-756689 Clorpromazina [INN-Spanish] 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine # Phenothiazine hydrochloride D01ZII 50-53-3 Prestwick2_000064 EINECS 200-045-8 AB0015094 Prozil GG 407 Amplicitil SC-50091 HMS501P06 Lomazine (Salt/Mix) BCP03610 SPECTRUM1500184 Spectrum4_000283 KBio2_004880 NCGC00015273-01 C06906 Thorazine hydrochloride KBioSS_002314 NCGC00015273-09 CHEMBL71 UNII-U42B7VYA4P NCGC00015273-17 Chlorpromados [3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine hydrochloride 1N,1N-dimethyl-3-(2-chloro-10H-10-phenothiazinyl)-1-propanamine Norcozine (Salt/Mix) Chlorpromazine [USP:INN:BAN] 2-Cloro-10 (3-dimetilaminopropil)fenotiazina NSC756689 Contomin 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine Plegomasine DivK1c_000624 AB00051943 Promactil Esmind ALBB-022464 QTL1_000021 HL 5746 Largactil (TN) API0001970 SKF 2601A IDI1_000624 LS-105361 Bio1_000946 BPBio1_000273 SR-01000000012-5 KBio3_001231 NCGC00015273-04 CAS-69-09-0 Torazina KSC-315-032- NCGC00015273-12 Chlordelazine WLN: T C666 BN ISJ B3N1&1 EG (chlorpromazine)[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine NCGC00024409-05 [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine( Chlorpromazine) 2-Chloro-10-(3-dimethylaminopropyl)phenothiazine NSC 167745 Chlorpromazinum [INN-Latin] 2601A Phenactyl CTK1C5154 4560 R.P. Prestwick0_000064 DSSTox_RID_76736 AB00051943_17 Propaphen Fraction AB Aminazine Sanopron HMS2091E06 Largactilothiazine BBL028251 SPBio_001111 KB-232587 MCULE-5976054678 KBio2_002312 MolPort-001-727-953 BSPBio_000247 Thorazine KBioGR_002312 NCGC00015273-07 CHEBI:3647 Tranzine (Salt/Mix) NCGC00015273-15 Chloro-3 (dimethylamino-3 propyl)-10 phenothiazine [French] ZPEIMTDSQAKGNT-UHFFFAOYSA-N 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl- NCGC00024409-08 Chlorpromazine Tannate 2-chloro-N,N-dimethyl-10H-Phenothiazine-10-propanamine NSC167745 Clorpromazina [Italian] 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine Phenothiazine, 2-chloro-10-(3-(dimethylamino)propyl)- Prestwick3_000064 Elmarin AC1L1EBT Psychozine GTPL83 L000182 Amplictil SCHEMBL8321 HSDB 3033 Lopac-C-8138 BDBM50001888 Spectrum2_001156 Bio1_001435 Spectrum5_000717 KBio2_005758 NCGC00015273-02 C17H19ClN2S Thorazine Spansule KS-00002WW5 NCGC00015273-10 Chlor-Promanyl Unitensen NCGC00015273-19 Chlorpromanyl (discontinued) [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine 2-chloro-10-(3-(dimethylamino)propyl)-phenothiazine Novo-Chlorpromazine Chlorpromazine;[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine 2-Cloro-10 (3-dimetilaminopropil)fenotiazina [Italian] Oprea1_110255 CPZ 34468-21-8 Plegomazin DSSTox_CID_2808 AB00051943-15 Promapar Fenactil Aminasine R1242 HMS1920M03 Largactil Liquid AX8120990 SKF-2601 J10069 M-1209 Megaphen BPBio1_001181 SR-01000000012-6 KBio3_002792 NCGC00015273-05 CCG-40059 Tox21_110120 KUC112482N NCGC00015273-13 Chlorderazin Z80 NCGC00024409-06 Chlorpromazine (USP/INN) [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine(clorpromazine) 2-chloro-10-[3-(dimethylamino)propyl]- NSC-167745 Clorpromazina 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine Phenathyl D00270 4560 Rp hydrochloride Prestwick1_000064 DTXSID0022808 AB00051943_18 Propaphenin FT-0653683 Ampliactil SBI-0050237.P004 HMS3430C19 Largactyl BC 135 SPBio_002168 KBio1_000624 KBio2_003190 N-(3-Dimethylaminopropyl)-3-chlorophenothiazine BSPBio_002011 Thorazine (TN) KBioSS_000622 NCGC00015273-08 U42B7VYA4P NCGC00015273-16 Chloropromazine [3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-, radical ion(1+) NINDS_000624 Chlorpromazine [USAN:INN:BAN] 2-Chloropromazine NSC17479 cMAP_000017 3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine Phenothiazine, 2-chloro-10-[3-(dimethylamino)propyl]- DB00477 Proma Epitope ID:136898 AKOS001490972 QSPL 401 Hibernal (Salt/Mix) Largactil AN-41563 SKF 2601-A I14-6226 Lopac0_000249 Bio1_000457 Spectrum3_000346 Biomol-NT_000020 Spectrum_000142 KBio2_007448 NCGC00015273-03 CAS-50-53-3 Thorazine Suppositories KS-5101 NCGC00015273-11 Chlor-PZ Wintermin (chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine NCGC00024409-04 Chlorpromazin [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine (chlor-promazine) 2-Chloro-10-(3-(dimethylamino)propyl)phenothiazine Novomazina Chlorpromazinum 2601-A Pharmakon1600-01500184 Cromedazine 4560 R.P Prazilpromactil DSSTox_GSID_22808 AB00051943-16 Promazil Fenaktyl Aminazin RP-4560 HMS2089C12 Largactil Oral Drops BAS 00010434 SMR001453710 JHICC02042 M176 [ Show all ]
Inchi Key	ZPEIMTDSQAKGNT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
PubChem CID	2726
ChEMBL	CHEMBL71
IUPHAR	83
BindingDB	50001888
DrugBank	DB00477
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1.99526 nM	PMID9655845	IUPHAR
Ki	2.0 nM	PMID1347569, PMID8524985	BindingDB
Ki	2.51 nM	PMID7908055	BindingDB
Ki	3.01 nM	PMID7984267	BindingDB
Ki	3.6 nM	PMID9686407	BindingDB
Ki	7.94 nM	PMID7984267	BindingDB
Ki	11.0 nM	PMID2795135	BindingDB
Ki	31.0 nM	PMID2869639	BindingDB

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