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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Formyl peptide receptor 2
Species	Mus musculus (Mouse)
Gene	Fpr2
Synonym	LXA4R Lipoxin A4 receptor-like protein FPRL1 N-formylpeptide receptor-like 2 FPRH2 FPRH1 FPR2A FPR2/ALX Fpr-rs2 Formylpeptide receptor-related sequence 2 formyl peptide receptor-like 1 formyl peptide receptor, related sequence 2 formyl peptide receptor 2 FMLPX ALXR ALX/FPR2 ALX RFP [ Show all ]
Disease	N/A for non-human GPCRs
Length	351
Amino acid sequence	MESNYSIHLNGSEVVVYDSTISRVLWILSMVVVSITFFLGVLGNGLVIWVAGFRMPHTVTTIWYLNLALADFSFTATLPFLLVEMAMKEKWPFGWFLCKLVHIVVDVNLFGSVFLIALIALDRCICVLHPVWAQNHRTVSLARKVVVGPWIFALILTLPIFIFLTTVRIPGGDVYCTFNFGSWAQTDEEKLNTAITFVTTRGIIRFLIGFSMPMSIVAVCYGLIAVKINRRNLVNSSRPLRVLTAVVASFFICWFPFQLVALLGTVWFKETLLSGSYKILDMFVNPTSSLAYFNSCLNPMLYVFMGQDFRERFIHSLPYSLERALSEDSGQTSDSSTSSTSPPADIELKAP
UniProt	O88536
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	N/A
IUPHAR	223
DrugBank	N/A

Ligand

Name	Pyrazolone, 1
Molecular formula	C20H21ClN4O2
IUPAC name	1-(4-chlorophenyl)-3-(1-methyl-3-oxo-2-phenyl-5-propan-2-ylpyrazol-4-yl)urea
Molecular weight	384.864
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	4.1
Synonyms	CHEMBL379761 NCGC00387180-01 3-(4-chlorophenyl)-1-(1-methyl-3-oxo-2-phenyl-5-propan-2-ylpyrazol-4-yl)urea AKOS025142013 Cpd43 T77D5438IM CHEMBL-379761 MolPort-035-941-175 ZINC14976923 1-(4-chlorophenyl)-3-[1-methyl-5-(1-methylethyl)-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl]urea compound 43 [PMID:16697190] AS-55050 D0WB8E TC-FPR 43 1-(4-Chlorophenyl)-3-(5-isopropyl-1-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)urea N-(4-Chlorophenyl)-N-[2,3-dihydro-1-methyl-5-(1-methylethyl)-3-oxo-2-phenyl-1H-pyrazol-4-yl]-urea compound 43 [PMID:23160941] SCHEMBL18894545 903895-98-7 BDBM21692 GTPL5831 UNII-T77D5438IM 1-(4-chlorophenyl)-3-[1-methyl-3-oxo-2-phenyl-5-(propan-2-yl)-2,3-dihydro-1H-pyrazol-4-yl]urea [ Show all ]
Inchi Key	PAEBEUZTAPIOIO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H21ClN4O2/c1-13(2)18-17(23-20(27)22-15-11-9-14(21)10-12-15)19(26)25(24(18)3)16-7-5-4-6-8-16/h4-13H,1-3H3,(H2,22,23,27)
PubChem CID	24776341
ChEMBL	CHEMBL379761
IUPHAR	5831
BindingDB	21692
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	120.226 nM	PMID23160941	IUPHAR

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