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GPCR

Name	Free fatty acid receptor 3
Species	Homo sapiens (Human)
Gene	FFAR3
Synonym	FFA3R FFA3 receptor G-protein coupled receptor 41 GPCR41 GPR41 LSSIG G protein-coupled receptor 41 [ Show all ]
Disease	N/A
Length	346
Amino acid sequence	MDTGPDQSYFSGNHWFVFSVYLLTFLVGLPLNLLALVVFVGKLQRRPVAVDVLLLNLTASDLLLLLFLPFRMVEAANGMHWPLPFILCPLSGFIFFTTIYLTALFLAAVSIERFLSVAHPLWYKTRPRLGQAGLVSVACWLLASAHCSVVYVIEFSGDISHSQGTNGTCYLEFRKDQLAILLPVRLEMAVVLFVVPLIITSYCYSRLVWILGRGGSHRRQRRVAGLLAATLLNFLVCFGPYNVSHVVGYICGESPAWRIYVTLLSTLNSCVDPFVYYFSSSGFQADFHELLRRLCGLWGQWQQESSMELKEQKGGEEQRADRPAERKTSEHSQGCGTGGQVACAES
UniProt	O14843
Protein Data Bank	N/A
GPCR-HGmod model	O14843
3D structure model	This predicted structure model is from GPCR-EXP O14843.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5201
IUPHAR	227
DrugBank	N/A

Ligand

Name	ISOBUTYRIC ACID
Molecular formula	C4H8O2
IUPAC name	2-methylpropanoic acid
Molecular weight	88.106
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	0.8
Synonyms	Propionic acid, 2-methyl- Tenox IBP-2 Grain Pr Z955123672 HSDB 5228 11047-EP2316828A1 Iso-butyric acid 2-methyl propanoic acid Isobutyric acid [UN2529] [Flammable liquid] 22228-82-6 (ammonium salt) Isobutyric acid, puriss. p.a., >=99.5% 88696-EP2305825A1 KS-00000X9W AC1Q1O87 Methylpropanoic acid, 2- alpha-Methylpropanoic acid NSC 62780 BRN 0635770 CTK3I9676 11047-EP2277848A1 DTXSID4021636 11047-EP2311816A1 SC-23341 TR-032122 11047-EP2316457A1 I0103 11047-EP2374787A1 Isobutanoic acid 2-METHYL-PROPIONIC ACID Isobutyric acid, 99+% 79-31-2 Isopropylformate a-Methylpropanoate Kyselina isomaselna [Czech] ACMC-209ph0 MolPort-001-783-185 ALQ Propanoic acid, 2-methyl- Caswell No. 503AA Dimethylacetate 11047-EP2298763A1 EPA Pesticide Chemical Code 101502 Tenox IBP 2 UNII-8LL210O1U0 FT-0625068 11047-EP2316826A1 ISB 1iup 2-Methylpropionsaeure Isobutyric acid, certified reference material, TraceCERT(R) 88696-EP2295411A1 KB-77935 a-Methylpropionic acid MCULE-7783770647 alpha-isobutyric acid NCGC00248957-01 BBL011415 11047-EP2272841A1 DSSTox_GSID_21636 11047-EP2308858A1 RP18490 Tenox IBP-2 Grain Pr. ZINC901420 i-butyrate 11047-EP2371803A1 iso-C3H7COOH 2-Methyl Propionic Acic, Natural Isobutyric acid [UN2529] [Flammable liquid] 4-02-00-00843 (Beilstein Handbook Reference) Isobutyricacid 8LL210O1U0 KSC489M7N AC1Q5RPW methylpropionic acid alpha-Methylpropionate NSC-62780 C02632 .alpha.-Methylpropanoic acid D06ZVB 11047-EP2289510A1 EC 201-195-7 11047-EP2311817A1 STL146521 UN 2529 11047-EP2316458A1 I14-10607 11047-EP2377843A1 Isobuttersaeure 2-Methylpropanoic acid Isobutyric acid, >=99%, FCC, FG 88696-EP2287158A1 Isopropylformic acid a-Methylpropanoic acid LMFA01020071 AI3-24260 Nat.Isobutyric Acid AN-23989 Cenex RP b2 11047-EP2269610A2 Dimethylacetic acid 11047-EP2298772A1 F2191-0099 Propanoic acid,2-methyl- Tenox IBP-2 WLN: QVY1&1 GTPL1060 11047-EP2316827A1 iso-Butyrate 2,2-dimethylacetic acid Isobutyric acid (natural) 2-Propanecarboxylic acid Isobutyric acid, natural, >=99%, FCC, FG 88696-EP2298777A2 KQNPFQTWMSNSAP-UHFFFAOYSA-N AC1L1MVA methylpropanoic acid alpha-Methylpropanoate NCGC00258759-01 bmse000439 CHEMBL108778 11047-EP2275401A1 DSSTox_RID_76250 11047-EP2311453A1 RTR-032122 Tox21_201207 11047-EP2311822A1 i-Butyric acid 11047-EP2374538A1 Isobutanoate 2-methyl-propanoic acid Isobutyric acid, 99% 533-90-4 (calcium salt) isopropyl carboxylic acid 996-30-5 (hydrochloride salt) Kyselina isomaselna Acetic acid, dimethyl- MFCD00002658 alpha-Methylpropionic acid NSC62780 CAS-79-31-2 .alpha.-Methylpropionic acid DB02531 11047-EP2295055A2 EINECS 201-195-7 Tenox EBP 2 UN2529 11047-EP2316825A1 InChI=1/C4H8O2/c1-3(2)4(5)6/h3H,1-2H3,(H,5,6 19455-20-0 (potassium salt) Isobutyrate 2-Methylpropionic acid Isobutyric acid, analytical standard 88696-EP2289876A1 K400 a-Methylpropionate LS-2857 AKOS000118733 NATURAL ISOBUTYRIC ACID ANW-37282 CHEBI:16135 11047-EP2270003A1 DSSTox_CID_1636 11047-EP2308839A1 FEMA No. 2222 [ Show all ]
Inchi Key	KQNPFQTWMSNSAP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C4H8O2/c1-3(2)4(5)6/h3H,1-2H3,(H,5,6)
PubChem CID	6590
ChEMBL	CHEMBL108778
IUPHAR	1060
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	15848.9 - 50118.7 nM	PMID12496283, PMID14722361	IUPHAR

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