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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled receptor 12
Species	Homo sapiens (Human)
Gene	GPR12
Synonym	GPR12 GPCR21 Gpcr20 GPCR12 Gpcr01 R334 [ Show all ]
Disease	N/A
Length	334
Amino acid sequence	MNEDLKVNLSGLPRDYLDAAAAENISAAVSSRVPAVEPEPELVVNPWDIVLCTSGTLISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFAYLLQSEATKLVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSVSFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKALCLICCGCIPSSLAQRARSPSDV
UniProt	P47775
Protein Data Bank	N/A
GPCR-HGmod model	P47775
3D structure model	This predicted structure model is from GPCR-EXP P47775.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	N/A
IUPHAR	86
DrugBank	BE0009153

Ligand

Name	sphingosylphosphorylcholine
Molecular formula	C23H49N2O5P
IUPAC name	[(E,2S,3R)-2-amino-3-hydroxyoctadec-4-enyl] 2-(trimethylazaniumyl)ethyl phosphate
Molecular weight	464.628
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	4.7
Synonyms	Sphingosine-1-phosphocholine Sphingosylphosphorylcholine, >=98.0% (TLC) 1670-26-4 C23H49N2O5P JLVSPVFPBBFMBE-HXSWCURESA-N MFCD02259287 SPHINGOSYLPHOSPHORYL CHOLINE 2-[[[[2S-Amino-3R-hydroxy-4E-octadecenyl]oxy]hydroxyphosphinyl]oxy]-N,N,N-trimethylethanaminium CHEMBL34522 Lyso SM (d18:1), Sphingosylphosphorylcholine, powder SCHEMBL19928025 (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl 2-(trimethylammonio)ethyl phosphate BDBM50289522 D0J4NQ LysoSM(d18:1) sphing-4-enine-1-phosphocholine sphingosyl phosphorylcholine Sphingosylphosphorylcholine, powder 2-[[[(2-Amino-3-hydroxy-4-octadecenyl)oxy]hydroxy-phosphinyl]oxy]-N,N,N-trimethylethanaminium inner salt CHEBI:17689 LMSP01060001 MolPort-003-939-313 Sphingosylphosphoryl-choline 2048AH D-erythro-sphingosine phosphocholine Lyso Sphingomyelin SM(d18:1/0:0) Sphingenyl-1-phosphorylcholine Sphingosylphosphorylcholine, >=98%, powder (2S,3R,4E)-2-Amino-4-octadecene-3-hydroxy-1-phosphocholine BML3-D07 GTPL4032 Lysosphingomyelin sphingosylphosphocholine betaine [(E,2S,3R)-2-amino-3-hydroxyoctadec-4-enyl] 2-trimethylazaniumylethyl phosphate 2-[[[[(2S,3R,4E)-2-Amino-3-hydroxy-4-octadecen-1-yl]oxy]hydroxyphosphinyl]oxy]-N,N,N-trimethyl-ethanaminium CHEMBL1481114 Lyso SM (d18:1) NCGC00161365-01 Sphingosylphosphorylchloline D-erythro-Sphingosylphosphorylcholine (Synthetic) lyso-Sphingomyelin SPC [ Show all ]
Inchi Key	JLVSPVFPBBFMBE-HXSWCURESA-N
Inchi ID	InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m0/s1
PubChem CID	9847290
ChEMBL	N/A
IUPHAR	4032
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	32.0 - 66.0 nM	PMID12574419	IUPHAR

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