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GPCR

Name	Free fatty acid receptor 3
Species	Homo sapiens (Human)
Gene	FFAR3
Synonym	FFA3R FFA3 receptor G-protein coupled receptor 41 GPCR41 GPR41 LSSIG G protein-coupled receptor 41 [ Show all ]
Disease	N/A
Length	346
Amino acid sequence	MDTGPDQSYFSGNHWFVFSVYLLTFLVGLPLNLLALVVFVGKLQRRPVAVDVLLLNLTASDLLLLLFLPFRMVEAANGMHWPLPFILCPLSGFIFFTTIYLTALFLAAVSIERFLSVAHPLWYKTRPRLGQAGLVSVACWLLASAHCSVVYVIEFSGDISHSQGTNGTCYLEFRKDQLAILLPVRLEMAVVLFVVPLIITSYCYSRLVWILGRGGSHRRQRRVAGLLAATLLNFLVCFGPYNVSHVVGYICGESPAWRIYVTLLSTLNSCVDPFVYYFSSSGFQADFHELLRRLCGLWGQWQQESSMELKEQKGGEEQRADRPAERKTSEHSQGCGTGGQVACAES
UniProt	O14843
Protein Data Bank	N/A
GPCR-HGmod model	O14843
3D structure model	This predicted structure model is from GPCR-EXP O14843.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5201
IUPHAR	227
DrugBank	N/A

Ligand

Name	butyric acid
Molecular formula	C4H8O2
IUPAC name	butanoic acid
Molecular weight	88.106
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	0.8
Synonyms	STL169349 24113-EP2292611A1 DB03568 UNII-40UIR9Q29H 24113-EP2311810A1 ethyl acetic acid 31560-EP2308858A1 GTPL1059 81544-EP2305808A1 Kyselina maselna [Czech] AI3-15306 n-Butyric acid, 99+% Bio1_001422 NCGC00259931-01 butanoate propylformic acid Butyrate, sodium salt Butyric acid, analytical standard 107-92-6 CAS-107-92-6 CH3-[CH2]2-COOH Tox21_202382 24113-EP2298772A1 DSSTox_RID_76192 WLN: QV3 24113-EP2311840A1 FEMA No. 2221 3umq I14-10596 AC1L18UM MCULE-4116382006 ANW-15867 Nat. Butyric Acid BRD-K05878375-236-02-4 NSC 8415 butanoic acid, butanic acid, n-butyric acid, ethylacetic acid, propylformic acid, 1-propanecarboxylic acid SC-11907 Butyric Acid (Normal) 1-butyrate Butyricum acidum 24113-EP2272827A1 24113-EP2284146A2 CTK0H6694 UN 2820 24113-EP2305808A1 EINECS 203-532-3 31560-EP2292597A1 FT-0623295 81544-EP2275407A1 KS-00000V2V acide butyrique n-Butanoic acid Bio1_000444 NCGC00247914-02 butanate propanecarboxylate Buttersaeure [German] Butyric acid, >=99% 1-propanecarboxylic acid C4:0 TNFa + NaBut 24113-EP2292619A1 DSSTox_CID_1515 V2319 24113-EP2311818A1 ethylacetic acid 31560-EP2311816A1 Honey robber 81544-EP2305825A1 LMFA01010004 AKOS000118961 N-butyric acid, ethyl acetic acid bmse000402 NCI60_001424 butanoic acid RL00334 1-butanoate Butyric acid, natural, >=99%, FCC, FG 1ugp CCG-35836 CHEBI:30772 Tox21_300164 24113-EP2305633A1 DTXSID8021515 Z955123634 24113-EP2314590A1 FEMA Number 2221 4-02-00-00779 (Beilstein Handbook Reference) InChI=1/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6 AC1Q2UNL MFCD00002814 B0754 NATURAL BUTYRIC ACID BRN 0906770 NSC-8415 butoic acid Butyric acid [UN2820] [Corrosive] 1-Butyric acid BUTYRIC_ACID 24113-EP2275401A1 Sodium n-butyrate 24113-EP2284147A2 D0T4JQ UN2820 24113-EP2308839A1 Ethyacetic Acid 31560-EP2295053A1 FT-0686717 81544-EP2305687A1 Kyselina maselna ACMC-1C12J n-Butyric acid Bio1_000933 NCGC00253919-01 Butanic acid Propanecarboxylic acid butyrate Butyric acid, >=99%, FG C4:0 (Lipid numbers) CCRIS 6552 TNFa + Sodium Butyrate 24113-EP2298763A1 DSSTox_GSID_21515 W-108732 24113-EP2311825A1 F2191-0094 31560-EP2311817A1 HSDB 940 9B27B3D0-9643-40EC-9A5F-7CA1A6ED7F9F LS-443 AN-42840 n-C3H7COOH BP-21420 NCIMech_000707 butanoic acid, 4 RTR-001881 Butyric acid (natural) 1-butanoic acid Butyric acid, SAJ special grade, >=99.5% 2-butanoate CHEMBL14227 TR-001881 24113-EP2305659A1 EC 203-532-3 ZINC895132 24113-EP2380661A2 FERIUCNNQQJTOY-UHFFFAOYSA-N 40UIR9Q29H KB-48536 acide butanoique MolPort-001-769-669 BDBM26109 NCGC00247914-01 BUA NSC8415 Buttersaeure Butyric acid [UN2820] [Corrosive] 1-propanecarboxylate C00246 24113-EP2281819A1 [ Show all ]
Inchi Key	FERIUCNNQQJTOY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)
PubChem CID	264
ChEMBL	N/A
IUPHAR	1059
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	12589.3 - 158489.0 nM	PMID12496283, PMID12711604, PMID14722361, PMID21220428	IUPHAR

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