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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Adenosine receptor A3
Species	Homo sapiens (Human)
Gene	ADORA3
Synonym	ARA3 Adenosine receptor A3 A3AR A3 receptor TGPCR1
Disease	Cerebrovascular ischaemia Malaria Ischemia Inflammation Hepatocellular carcinoma; Hepatitis C virus infection Glaucoma Cancer [ Show all ]
Length	318
Amino acid sequence	MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
UniProt	P0DMS8
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T36059
ChEMBL	CHEMBL256
IUPHAR	21
DrugBank	BE0000354

Ligand

Name	Sakuranetin
Molecular formula	C16H14O5
IUPAC name	(2S)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-2,3-dihydrochromen-4-one
Molecular weight	286.283
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	2.7
Synonyms	D0B7OW MolPort-039-052-519 ZINC338284 (2S)-5,4'-dihydroxy-7-methoxyflavan-4-one (S)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxychroman-4-one 4h-1-benzopyran-4-one, 2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-,(2s)- AJ-19903 Flavanone, 4',5-dihydroxy-7-methoxy-, (S)-(-)- (8CI) (2S)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-chroman-4-one 3O38P61299 5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-chroman-4-one C09833 CHEMBL448297 GTPL412 UNII-3O38P61299 (2S)--5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-2,3-dihydrochromen-4-one (S)-(-)-4',5-dihydroxy-7-methoxyflavanone 4H-1-Benzopyran-4-one, 2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-, (2S)- AC1L2K3P DB08517 Naringenin 7-methyl ether (2S)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-2,3-dihydro-4H-chromen-4-one 2957-21-3 5,4''-dihydroxy-7-methoxyflavanone AKOS027321114 FT-0081262 Sakuranetin, analytical standard (2S)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxychroman-4-one 4',5-Dihydroxy-7-methoxyflavanone CHEBI:28927 D07IYH LMPK12140571 ZB010902 (2S)-4',5-dihydroxy-7-methoxyflavanone (S)-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one 4H-1-Benzopyran-4-one, 2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-, (S)- (9CI) AC1Q6KIJ EINECS 220-980-5 NSC 407228 (2S)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-2,3-dihydrochromen-4-one 3d04 5,4'-Dihydroxy-7-methoxyflavanone BDBM50312648 FT-0650767 SCHEMBL555542 (2S)-sakuranetin 7-O-Methylnaringenin [ Show all ]
Inchi Key	DJOJDHGQRNZXQQ-AWEZNQCLSA-N
Inchi ID	InChI=1S/C16H14O5/c1-20-11-6-12(18)16-13(19)8-14(21-15(16)7-11)9-2-4-10(17)5-3-9/h2-7,14,17-18H,8H2,1H3/t14-/m0/s1
PubChem CID	73571
ChEMBL	CHEMBL448297
IUPHAR	412
BindingDB	50312648
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	3162.28 nM	PMID8691424	IUPHAR

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