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GPCR

Name	Alpha-1B adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra1b
Synonym	adrenergic receptor alpha 1B-adrenoceptor alpha 1B-adrenoreceptor adrenergic alpha 1B receptor Alpha-1B adrenoceptor Alpha-1B adrenoreceptor alpha1B-adrenergic receptor alpha1B-adrenoceptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	515
Amino acid sequence	MNPDLDTGHNTSAPAHWGELKDDNFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRGGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGTQRTLPSASPSPGYLGRGTQPPVELCAFPEWKPGALLSLPEPPGRRGRLDSGPLFTFKLLGDPESPGTEGDTSNGGCDTTTDLANGQPGFKSNMPLAPGHF
UniProt	P15823
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL315
IUPHAR	23
DrugBank	N/A

Ligand

Name	lorazepam
Molecular formula	C15H10Cl2N2O2
IUPAC name	7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one
Molecular weight	321.157
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	2.4
Synonyms	Lorat Anzepam Lorazepam (JP15/USP/INN) Aripax Lorazepam Desitin Brand Bonatranquan Lorazepam Medical CPD000058410 Lorazepam preservative free Delormetazepam DSSTox_GSID_23225 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy- Emotival 7-Chloro-5-(2-chloro-phenyl)-3-hydroxy-1,3-dihydro-benzo[e][1,4]diazepin-2-one Idalprem 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one Llorens Brand of Lorazepam AC1L1H3H Securit Sinestron Lorazepam [USAN:INN:BAN:JAN] Tox21_111669 LORAZEPAM7-Chloro-5-(2-chloro-phenyl)-3-hydroxy-1,3-dihydro-benzo[e][1,4]diazepin-2-one WY4036 Loridem Medical Brand of Lorazepam Nervistop L Novo-Lorazem Nu-Loraz Punktyl Lorazene Aplacassee Lorazepam 1.0 mg/ml in Acetonitrile Ativan and others Lorazepam for system suitability, European Pharmacopoeia (EP) Reference Standard BRN 0759084 Lorazepam neuraxpharm CTK3E8194 Lorazepam Riemser Brand DivK1c_000965 (.+/-.)-Lorazepam Duralozam 5-25-02-00248 (Beilstein Handbook Reference) GTPL5884 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepine-2-one KBio1_000965 7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one Lorabenz Almazine Sedicepan Stapam Lorazepam, European Pharmacopoeia (EP) Reference Standard Upan Lorazepan Chobet Wypax Lorsilan Merck dura Brand of Lorazepam NINDS_000965 NSC 289758 o-Chlorooxazepam Renaquil Anxiedin ApoLorazepam Lorazepam Baxter Brand BCP13713 Lorazepam Lannacher CHEBI:6539 Lorazepam Novopharm Brand DB00186 Donix 2H-1, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy- EINECS 212-687-6 7-chloro-3-hydroxy-5-(2'-chloro-phenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-one HMS503A11 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one Larpose 846L491 Lorans SAM001246833 Sidenar Lorazepam solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material Temesta (TN) Lorazepam-neuraxpharm Wy 4036 Lorazon LS-34141 NC00420 Novhepar Nu Loraz Orfidal Wyeth Lorax API0001556 Lorazepam (JP17/USP/INN) Ativan Lorazepam Dolorgiet Brand Bonton Lorazepam Medical Brand ct Arzneimittel Brand of Lorazepam Lorazepam ratiopharm Demethyllormetazepam (+-)-7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one DSSTox_RID_76932 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-, (+-)- Equitam 7-Chloro-5-(2-chloro-phenyl)-3-hydroxy-1,3-dihydro-benzo[e][1,4]diazepin-2-one (lorazepam) IDI1_000965 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-benzo[e][1,4]diazepin-2(3H)-one Lomesta AHP Brand of Lorazepam Sedatival SMR000058410 Lorazepam [USAN:USP:INN:BAN:JAN] Tranqipam Lorazepamum Wyeth Brand of Lorazepam Lorivan Medical, Lorazepam Nervistopl Novolorazem Nu-Pharm Brand of Lorazepam Quait Lorazep Apo Lorazepam Lorazepam AHP Brand Azurogen Lorazepam Genericon CAS-846-49-1 Lorazepam neuraxpharm Brand D00365 DIWRORZWFLOCLC-UHFFFAOYSA-N (RS)-9-chloro-6-(2-chlorophenyl)-4-hydroxy-2,5-diazabicyclo[5.4.0]undeca-5,8,10,12-tetraen-3-one Durazolam HMS2052H07 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one L-230 7-Chloro-5-(o-chlorophenyl)-1,4-benzodiazepin-2-one Lorafen Alzapam Riemser Brand of Lorazepam Sedizepan Tavor Lorazepam, United States Pharmacopeia (USP) Reference Standard Vigiten Lorazepan Richet Lorzem Merlit Norlormetazepam NSC-289758 o-Chloroxazepam Anxira lorazepam (Ativan) Apotex Brand of Lorazepam Lorazepam ct-Arzneimittel Brand BDBM50292627 Lorazepam Llorens Brand CHEMBL580 Lorazepam Nu-Pharm Brand DEA No. 2885 DSSTox_CID_3225 2H-1, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy- Emotion 7-chloro-3-hydroxy-5-(2'-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-one I14-16542 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one # Laubeel A840886 Lorapam SCHEMBL26961 Silence Lorazepam Wyeth Brand Tolid Lorazepam-ratiopharm Wy-4036 Lorenin Max Pax NCGC00159439-02 Novo Lorazem Nu Pharm Brand of Lorazepam Pro dorm Loraz Aplacasse Lorazepam 0.1 mg/ml in Acetonitrile Ativan (TN) Lorazepam Fabra BRD-A11990600-001-01-8 Lorazepam Medix Brand ct-Arzneimittel Brand of Lorazepam Lorazepam ratiopharm Brand Desitin Brand of Lorazepam (+/-)-Lorazepam DTXSID7023225 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy- FT-0670847 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one Kalmalin 7-chloro-5-(2-chlorophenyl)-3-hydroxy-2,3-dihydro-1H-1,4-benzodiazepin-2-one Lopam AKOS015904303 Sedazin Somagerol Lorazepam, British Pharmacopoeia (BP) Reference Standard Trapax Lorazepamum [INN-Latin] Wyeth, Orfidal Lorsedal Medix Brand of Lorazepam neuraxpharm Brand of Lorazepam Novopharm Brand of Lorazepam NuLoraz ratiopharm Brand of Lorazepam AN-20537 lorazep von ct Apo-Lorazepam Lorazepam Apotex Brand Baxter Brand of Lorazepam Lorazepam Intensol CCG-101170 Lorazepam Novartis Brand D0E0OG Dolorgiet Brand of Lorazepam 2H,1,4-Benzodiazepin-2-one, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy- Efasedan 7-chloranyl-5-(2-chlorophenyl)-3-oxidanyl-1,3-dihydro-1,4-benzodiazepin-2-one HMS3394H07 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one. L1764_SIGMA 846-49-1 Loram Rocosgen Serra Pamies Brand of Lorazepam Temesta Lorazepam-Efeka WLN: T67 GMV JN IHJ CG IQ KR BG Lorazin Lozepam MLS001424236 Novartis Brand of Lorazepam NSC289758 Orfidal [ Show all ]
Inchi Key	DIWRORZWFLOCLC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H10Cl2N2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20)
PubChem CID	3958
ChEMBL	N/A
IUPHAR	5884
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	170000.0 nM	PMID10565838	IUPHAR

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