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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Prostaglandin E2 receptor EP1 subtype
Species	Rattus norvegicus (Rat)
Gene	Ptger1
Synonym	EP1 prostanoid receptor EP1 receptor PGE receptor EP1 subtype PGE2 receptor EP1 subtype prostaglandin E receptor 1 (subtype EP1), 42kDa prostanoid EP1 receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	405
Amino acid sequence	MSPYGLNLSLVDEATTCVTPRVPNTSVVLPTGGNGTSPALPIFSMTLGAVSNVLALALLAQVAGRLRRRRSTATFLLFVASLLAIDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTQPLIHAARVSVARARLALALLAAMALAVALLPLVHVGHYELQYPGTWCFISLGPPGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRARWRRRRSRRFRENAGPDDRRRWGSRGLRLASASSASSITSTTAALRSSRGGGSARRVHAHDVEMVGQLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQAMLRQLLRLLPLRVSAKGGPTELSLTKSAWEASSLRSSRHSGFSHL
UniProt	P70597
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5068
IUPHAR	340
DrugBank	N/A

Ligand

Name	AH 6809
Molecular formula	C17H14O5
IUPAC name	9-oxo-6-propan-2-yloxyxanthene-2-carboxylic acid
Molecular weight	298.294
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	3.9
Synonyms	C17H14O5 DTXSID80187106 L000101 SR-01000597664 6-Isopropoxy-9-xanthone-2-carboxylic acid AH6809, >=98%, crystalline solid or supercooled liquid HMS3648F13 NCGC00024721-01 Tocris-0671 33458-93-4 9H-Xanthene-2-carboxylic acid, 6-(1-methylethoxy)-9-oxo- AC1Q5UST BDBM85184 CTK1C3251 KB-74545 PDSP2_001532 6-isopropoxy-9-oxo-9h-xanthene-2-carboxylic acid AH-6809 CAS_33458-93-4 GTPL1896 LS-174420 SR-01000597664-1 AKOS024458601 CHEMBL1317823 HY-10418 NSC_119461 W-5361 3425AH 9H-Xanthene-2-carboxylicacid, 6-(1-methylethoxy)-9-oxo- ACM33458934 BRD-K59339270-001-01-8 D0J9PG KS-0000180F SCHEMBL1163801 6-Isopropoxy-9-oxoxanthene-2-carboxylic acid AH6809 CHEBI:95289 HMS3266H17 MolPort-009-018-350 SR-01000597664-2 9-oxo-6-propan-2-yloxyxanthene-2-carboxylic acid AC1L3OV2 AQFFXPQJLZFABJ-UHFFFAOYSA-N CS-1549 J-019193 PDSP1_001548 ZINC3995668 6-(1-Methylethoxy)-9-oxo-9H-xanthene-2-carboxylic acid [ Show all ]
Inchi Key	AQFFXPQJLZFABJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H14O5/c1-9(2)21-11-4-5-12-15(8-11)22-14-6-3-10(17(19)20)7-13(14)16(12)18/h3-9H,1-2H3,(H,19,20)
PubChem CID	119461
ChEMBL	CHEMBL1317823
IUPHAR	1896
BindingDB	85184
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1258.93 nM	PMID9537820	IUPHAR

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