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GPCR

Name	Cholecystokinin receptor type A
Species	Rattus norvegicus (Rat)
Gene	Cckar
Synonym	CCK-A receptor CCK-AR CCK1 receptor CCK1-R cholecystokinin receptor type A cholecystokinin-1 receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MSHSPARQHLVESSRMDVVDSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSALQILLYSIIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPSDAMQQSWQTFLLLILFLLPGIVMVVAYGLISLELYQGIKFDASQKKSAKEKKPSTGSSTRYEDSDGCYLQKSRPPRKLELQQLSSGSGGSRLNRIRSSSSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAEKHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGVRGEVGEEEDGRTIRALLSRYSYSHMSTSAPPP
UniProt	P30551
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2871
IUPHAR	76
DrugBank	N/A

Ligand

Name	rebamipide
Molecular formula	C19H15ClN2O4
IUPAC name	2-[(4-chlorobenzoyl)amino]-3-(2-oxo-1H-quinolin-4-yl)propanoic acid
Molecular weight	370.789
Hydrogen bond acceptor	4
Hydrogen bond donor	3
XlogP	2.4
Synonyms	MolPort-003-666-633 2-(4-chlorobenzoylamino)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propionic acid NCGC00095161-03 4-Quinolinepropanoic acid, 1,2-dihydro-alpha-((4-chlorobenzoyl)amino)-2-oxo-, (+-)- OPC-759 A843443 Rebamipida AC1L1JHF Rebamipidum [INN-Latin] ANW-42341 Spectrum2_000039 CAS-90098-04-7 SW199113-2 D01121 FT-0655225 KBio3_002880 111911-87-6 2-(4-chloro-benzoylamino)-3-(2-oxo-1,2-dihydro-quinolin-4-yl)-propionic acid Mucosta hydrate 2-(4-chlorobenzoylamino)-3-[2(1H)-quinolinon-4-yl]propionic acid NSC-758955 4-Quinolinepropanoicacid,a-[(4-chlorobenzoyl)amino]-1,2-dihydro-2-oxo- Proamipide AB01275518_02 Rebamipide (JP17/INN) AKOS005721106 SC-15936 BCP07230 SR-05000001520-1 CHEBI:93814 DSSTox_CID_25937 HMS2090L13 (+-)-1,2-Dihydro-alpha-((4-chlorobenzoyl)amino)-2-oxo-4-quinolinepropanoic acid LS-142128 2-(4-Chlorobenzoylamino)-3-(1,2-dihydro-2-oxo-4-quinolyl)propionic acid NCGC00095161-01 2-[[(4-chlorophenyl)-oxomethyl]amino]-3-(2-oxo-1H-quinolin-4-yl)propanoic acid OPC 12759 hydrate 911R876 QUI103 AC-6841 Rebamipide [INN:JAN] AN-35058 SPBio_000137 BSPBio_003559 STK577121 CS-2416 DTXSID8045937 HY-B0360 (+-)-alpha-(p-Chlorobenzamido)-1,2-dihydro-2-oxo-4-quinolinepropionic acid MLS006011883 Mucosta 2-(4-chlorobenzoylamino)-3-(2-quinolon-4-yl)propionic acid NCGC00095161-04 4-Quinolinepropanoic acid, 1,2-dihydro-alpha-((4-chlorobenzoyl)amino)-2-oxo-,(+-)- Pharmakon1600-01505310 AB0073108 Rebamipida [INN-Spanish] AK316145 s2032 AOB5606 Spectrum3_001959 CCG-39619 Tox21_111460 D03BQP GTPL871 KS-00000SHL 111911-87-6 (anhyd.) 2-(4-chlorobenzamido)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid N-[(4-chlorophenyl)carbonyl]-3-(2-hydroxyquinolin-4-yl)alanine 2-[(4-chlorobenzoyl)amino]-3-(2-oxo-1H-quinolin-4-yl)propanoic acid NSC758955 Proamipide hydrate AB01275518_03 rebamipide 111911-87-6 ALLWOAVDORUJLA-UHFFFAOYSA-N SCHEMBL221527 BRD-A15909516-001-02-5 SR-05000001520-2 CHEMBL1697771 DSSTox_GSID_45937 HMS3655L11 (+-)-2-(4-Chlorobenzoylamino)-3-(2(1H)-quinolinon-4-yl)propionic acid MCULE-3675104222 MolPort-000-781-642 2-(4-chlorobenzoylamino)-3-(2(1H)-quinolinon-4-yl)propionic acid NCGC00095161-02 4-Quinolinepropanic acid, alpha-((4-chlorobenzoyl)amino)-1,2-dihydro-2-oxo-, (+-)- OPC-12759 A802443 R0085 AC-7588 Rebamipidum AN-9620 SPECTRUM1505310 C19H15ClN2O4 STL146407 CTK8B3342 FT-0630971 I14-0511 (+/-)-2-(4-CHLOROBENZOYLAMINO)-3-(2(1H)-QUINOLINON-4-YL)-PROPIONIC ACID Mucosta (TN) 2-(4-chlorobenzoylamino)-3-[2(1h)-quinolinon-4-yl] propionic acid NCGC00095161-05 4-Quinolinepropanoic acid, \|A-[(4-chlorobenzoyl)amino]-1,2-dihydro-2-oxo- Pramipide AB01275518-01 AKOS005501649 SBI-0207054.P001 BBL011328 SR-05000001520 CCRIS 3585 Tox21_111460_1 DB11656 HMS1922B20 LS-142127 139344-42-6 2-(4-Chlorobenzamido)-3-[2(1H)-quinolinon-4-yl]propionic Acid N-[(4-chlorophenyl)carbonyl]-3-(2-oxo-1,2-dihydroquinolin-4-yl)alanine 2-[(4-chlorophenyl)carbonylamino]-3-(2-oxidanylidene-1H-quinolin-4-yl)propanoic acid OPC 12759 90098-04-7 Q-201660 AB1009629 Rebamipide hydrate alpha-[(4-Chlorobenzoyl)amino]-1,2-dihydro-2-oxo-4-quinolinepropanoic acid hydrate SMR003309276 BRD-A15909516-001-03-3 SR-05000001520-3 CR0013 DSSTox_RID_81235 HMS3714A15 (+-)-alpha-((4-Chlorobenzoyl)amino)-1,2-dihydro-2-oxo-4-quinolinepropanic acid MFCD11114396 [ Show all ]
Inchi Key	ALLWOAVDORUJLA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H15ClN2O4/c20-13-7-5-11(6-8-13)18(24)22-16(19(25)26)9-12-10-17(23)21-15-4-2-1-3-14(12)15/h1-8,10,16H,9H2,(H,21,23)(H,22,24)(H,25,26)
PubChem CID	5042
ChEMBL	N/A
IUPHAR	871
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	39810.7 nM	PMID15556137	IUPHAR

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