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GPCR

NameFree fatty acid receptor 3
SpeciesHomo sapiens (Human)
GeneFFAR3
SynonymFFA3R
FFA3 receptor
G-protein coupled receptor 41
GPCR41
GPR41
[ Show all ]
DiseaseN/A
Length346
Amino acid sequenceMDTGPDQSYFSGNHWFVFSVYLLTFLVGLPLNLLALVVFVGKLQRRPVAVDVLLLNLTASDLLLLLFLPFRMVEAANGMHWPLPFILCPLSGFIFFTTIYLTALFLAAVSIERFLSVAHPLWYKTRPRLGQAGLVSVACWLLASAHCSVVYVIEFSGDISHSQGTNGTCYLEFRKDQLAILLPVRLEMAVVLFVVPLIITSYCYSRLVWILGRGGSHRRQRRVAGLLAATLLNFLVCFGPYNVSHVVGYICGESPAWRIYVTLLSTLNSCVDPFVYYFSSSGFQADFHELLRRLCGLWGQWQQESSMELKEQKGGEEQRADRPAERKTSEHSQGCGTGGQVACAES
UniProtO14843
Protein Data BankN/A
GPCR-HGmod modelO14843
3D structure modelThis predicted structure model is from GPCR-EXP O14843.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5201
IUPHAR227
DrugBankN/A

Ligand

NameCHEMBL3926143
Molecular formulaC34H42ClNO4
IUPAC name3-[4-[[4-[[4-[(4-methylphenyl)methyl]-1-oxa-9-azaspiro[5.5]undecan-9-yl]methyl]phenyl]methoxy]phenyl]propanoic acid;hydrochloride
Molecular weight564.163
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogPNone
SynonymsBDBM50200350
Inchi KeyRRAJXYIZBSSZOQ-UHFFFAOYSA-N
Inchi IDInChI=1S/C34H41NO4.ClH/c1-26-2-4-28(5-3-26)22-31-16-21-39-34(23-31)17-19-35(20-18-34)24-29-6-8-30(9-7-29)25-38-32-13-10-27(11-14-32)12-15-33(36)37;/h2-11,13-14,31H,12,15-25H2,1H3,(H,36,37);1H
PubChem CID134141489
ChEMBLCHEMBL3926143
IUPHARN/A
BindingDB50200350
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
EC50<10000.0 nMPMID27647366BindingDB,ChEMBL

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