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GPCR

NameFree fatty acid receptor 3
SpeciesHomo sapiens (Human)
GeneFFAR3
SynonymFFA3R
FFA3 receptor
G-protein coupled receptor 41
GPCR41
GPR41
[ Show all ]
DiseaseN/A
Length346
Amino acid sequenceMDTGPDQSYFSGNHWFVFSVYLLTFLVGLPLNLLALVVFVGKLQRRPVAVDVLLLNLTASDLLLLLFLPFRMVEAANGMHWPLPFILCPLSGFIFFTTIYLTALFLAAVSIERFLSVAHPLWYKTRPRLGQAGLVSVACWLLASAHCSVVYVIEFSGDISHSQGTNGTCYLEFRKDQLAILLPVRLEMAVVLFVVPLIITSYCYSRLVWILGRGGSHRRQRRVAGLLAATLLNFLVCFGPYNVSHVVGYICGESPAWRIYVTLLSTLNSCVDPFVYYFSSSGFQADFHELLRRLCGLWGQWQQESSMELKEQKGGEEQRADRPAERKTSEHSQGCGTGGQVACAES
UniProtO14843
Protein Data BankN/A
GPCR-HGmod modelO14843
3D structure modelThis predicted structure model is from GPCR-EXP O14843.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5201
IUPHAR227
DrugBankN/A

Ligand

NameCHEMBL3963542
Molecular formulaC33H40ClNO4
IUPAC name3-[4-[[4-[(4-benzyl-1-oxa-9-azaspiro[5.5]undecan-9-yl)methyl]phenyl]methoxy]phenyl]propanoic acid;hydrochloride
Molecular weight550.136
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogPNone
SynonymsBDBM50200363
Inchi KeyKJXPELYXGINIOF-UHFFFAOYSA-N
Inchi IDInChI=1S/C33H39NO4.ClH/c35-32(36)15-12-26-10-13-31(14-11-26)37-25-29-8-6-28(7-9-29)24-34-19-17-33(18-20-34)23-30(16-21-38-33)22-27-4-2-1-3-5-27;/h1-11,13-14,30H,12,15-25H2,(H,35,36);1H
PubChem CID134151150
ChEMBLCHEMBL3963542
IUPHARN/A
BindingDB50200363
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
EC50<10000.0 nMPMID27647366BindingDB,ChEMBL

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