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Name | Growth hormone secretagogue receptor type 1 |
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Species | Homo sapiens (Human) |
Gene | GHSR |
Synonym | ghrelin receptor GH-releasing peptide receptor GHRP GHS-R growth hormone-releasing peptide receptor [ Show all ] |
Disease | N/A |
Length | 366 |
Amino acid sequence | MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT |
UniProt | Q92847 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q92847 |
3D structure model | This predicted structure model is from GPCR-EXP Q92847. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4616 |
IUPHAR | 246 |
DrugBank | BE0003383 |
Name | CHEMBL3925748 |
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Molecular formula | C31H41N5O4 |
IUPAC name | (6S,12S,16Z)-6-(2-methylpropyl)-12-(pyridin-3-ylmethyl)spiro[2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),16,18,20-tetraene-9,1'-cyclopentane]-7,10,13-trione |
Molecular weight | 547.7 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 4 |
XlogP | 3.6 |
Synonyms | N/A |
Inchi Key | AMSWIOQYWAFJQW-AXKKTZCFSA-N |
Inchi ID | InChI=1S/C31H41N5O4/c1-22(2)19-25-29(38)36-31(13-5-6-14-31)30(39)35-26(20-23-9-7-15-32-21-23)28(37)34-16-8-11-24-10-3-4-12-27(24)40-18-17-33-25/h3-4,7-12,15,21-22,25-26,33H,5-6,13-14,16-20H2,1-2H3,(H,34,37)(H,35,39)(H,36,38)/b11-8-/t25-,26-/m0/s1 |
PubChem CID | 134141672 |
ChEMBL | CHEMBL3925748 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | <1000.0 nM | None | ChEMBL |
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