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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Urotensin-2 receptor
Species	Rattus norvegicus (Rat)
Gene	Uts2r
Synonym	UT receptor urotensin II receptor UR-II-R UR-2-R UII-R1 SENR (sensory epithelial neuropeptide-like receptor) SENR GPR14 G-protein coupled sensory epithelial neuropeptide-like receptor G-protein coupled receptor 14 G protein-coupled receptor 14 UTR2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	386
Amino acid sequence	MALSLESTTSFHMLTVSGSTVTELPGDSNVSLNSSWSGPTDPSSLKDLVATGVIGAVLSAMGVVGMVGNVYTLVVMCRFLRASASMYVYVVNLALADLLYLLSIPFIIATYVTKDWHFGDVGCRVLFSLDFLTMHASIFTLTIMSSERYAAVLRPLDTVQRSKGYRKLLVLGTWLLALLLTLPMMLAIQLVRRGSKSLCLPAWGPRAHRTYLTLLFGTSIVGPGLVIGLLYVRLARAYWLSQQASFKQTRRLPNPRVLYLILGIVLLFWACFLPFWLWQLLAQYHEAMPLTPETARIVNYLTTCLTYGNSCINPFLYTLLTKNYREYLRGRQRSLGSSCHSPGSPGSFLPSRVHLQQDSGRSLSSSSQQATETLMLSPVPRNGALL
UniProt	P49684
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4921
IUPHAR	365
DrugBank	N/A

Ligand

Name	CHEMBL565388
Molecular formula	C38H44N6O5
IUPAC name	N-[(4R)-4-(3,4-dimethoxyphenyl)-4-[1,3-dioxo-4-[4-[(1R)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]butyl]-3,5-dimethyl-1H-pyrazole-4-carboxamide
Molecular weight	664.807
Hydrogen bond acceptor	8
Hydrogen bond donor	2
XlogP	5.0
Synonyms	SCHEMBL1472946 BDBM50302254 N-((R)-4-(3,4-dimethoxyphenyl)-4-(1,3-dioxo-4-(4-((R)-1-phenylethyl)piperazin-1-yl)isoindolin-2-yl)butyl)-3,5-dimethyl-1H-pyrazole-4-carboxamide
Inchi Key	CZWJHNWGEGYHNZ-PDDLMNHVSA-N
Inchi ID	InChI=1S/C38H44N6O5/c1-24-34(25(2)41-40-24)36(45)39-18-10-15-30(28-16-17-32(48-4)33(23-28)49-5)44-37(46)29-13-9-14-31(35(29)38(44)47)43-21-19-42(20-22-43)26(3)27-11-7-6-8-12-27/h6-9,11-14,16-17,23,26,30H,10,15,18-22H2,1-5H3,(H,39,45)(H,40,41)/t26-,30-/m1/s1
PubChem CID	44596967
ChEMBL	CHEMBL565388
IUPHAR	N/A
BindingDB	50302254
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	11.0 nM	PMID19731961	BindingDB,ChEMBL

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