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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Uracil nucleotide/cysteinyl leukotriene receptor
Species	Homo sapiens (Human)
Gene	GPR17
Synonym	GPR17 P2Y-like receptor G-protein coupled receptor 17 R12 UDP/CysLT receptor uracil nucleotide/cysteinyl leukotriene receptor [ Show all ]
Disease	N/A
Length	367
Amino acid sequence	MSKRSWWAGSRKPPREMLKLSGSDSSQSMNGLEVAPPGLITNFSLATAEQCGQETPLENMLFASFYLLDFILALVGNTLALWLFIRDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHFSGNHWPFGEIACRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLACAFLWVVVAVAMAPLLVSPQTVQTNHTVVCLQLYREKASHHALVSLAVAFTFPFITTVTCYLLIIRSLRQGLRVEKRLKTKAVRMIAIVLAIFLVCFVPYHVNRSVYVLHYRSHGASCATQRILALANRITSCLTSLNGALDPIMYFFVAEKFRHALCNLLCGKRLKGPPPSFEGKTNESSLSAKSEL
UniProt	Q13304
Protein Data Bank	N/A
GPCR-HGmod model	Q13304
3D structure model	This predicted structure model is from GPCR-EXP Q13304.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1075162
IUPHAR	88
DrugBank	N/A

Ligand

Name	CHEMBL3921330
Molecular formula	C15H13Cl2NO6
IUPAC name	1,3-bis(2-carboxyethyl)-4,6-dichloroindole-2-carboxylic acid
Molecular weight	374.17
Hydrogen bond acceptor	6
Hydrogen bond donor	3
XlogP	2.3
Synonyms	SCHEMBL14738932
Inchi Key	YMVOSFQQMGHRKY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H13Cl2NO6/c16-7-5-9(17)13-8(1-2-11(19)20)14(15(23)24)18(10(13)6-7)4-3-12(21)22/h5-6H,1-4H2,(H,19,20)(H,21,22)(H,23,24)
PubChem CID	71280744
ChEMBL	CHEMBL3921330
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	80.0 %	None	ChEMBL
Activity	85.0 %	None	ChEMBL
EC50	186.21 nM	None	ChEMBL
EC50	5248.07 nM	None	ChEMBL

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