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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1279151
Molecular formula	C23H21NO5S
IUPAC name	4-[(6-methoxy-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]benzoic acid
Molecular weight	423.483
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	3.8
Synonyms	US9247759, 5-162 CHEMBL3964825 BDBM211215
Inchi Key	SOJMQGNUYPSHEH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H21NO5S/c1-29-19-9-12-21-18(15-19)13-14-24(22(21)16-5-3-2-4-6-16)30(27,28)20-10-7-17(8-11-20)23(25)26/h2-12,15,22H,13-14H2,1H3,(H,25,26)
PubChem CID	57422407
ChEMBL	CHEMBL3964825
IUPHAR	N/A
BindingDB	211215
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	9616.0 nM	None	ChEMBL
IC50	9616.0 nM	N/A	BindingDB

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