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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	C-C chemokine receptor-like 2
Species	Homo sapiens (Human)
Gene	CCRL2
Synonym	ACR5 CRAM-B CRAM-A CKRX Chemokine receptor X Chemokine receptor CCR11 CCRL2 CCR6 CCR11 Putative MCP-1 chemokine receptor [ Show all ]
Disease	N/A
Length	344
Amino acid sequence	MANYTLAPEDEYDVLIEGELESDEAEQCDKYDAQALSAQLVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAGGDPMCKILIGLYFVGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFLPADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYLCRCFHLRSNTPLQPRGQSAQGTSREEPDHSTEV
UniProt	O00421
Protein Data Bank	N/A
GPCR-HGmod model	O00421
3D structure model	This predicted structure model is from GPCR-EXP O00421.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2321627
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL3986134
Molecular formula	C24H33F2N5O
IUPAC name	2-[[6-(1,1-difluoroethyl)quinazolin-4-yl]amino]-N-[1-(4-propan-2-ylcyclohexyl)azetidin-3-yl]acetamide
Molecular weight	445.559
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	4.7
Synonyms	US9062048, 118 BDBM60423
Inchi Key	DDGRFRKRHPEXOC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H33F2N5O/c1-15(2)16-4-7-19(8-5-16)31-12-18(13-31)30-22(32)11-27-23-20-10-17(24(3,25)26)6-9-21(20)28-14-29-23/h6,9-10,14-16,18-19H,4-5,7-8,11-13H2,1-3H3,(H,30,32)(H,27,28,29)
PubChem CID	118987381
ChEMBL	CHEMBL3986134
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	85.0 nM	None	ChEMBL

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