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Name | Cysteinyl leukotriene receptor 1 |
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Species | Homo sapiens (Human) |
Gene | CYSLTR1 |
Synonym | LTD4 receptor LTD4 leukotriene D4 receptor HMTMF81 HG55 [ Show all ] |
Disease | N/A |
Length | 337 |
Amino acid sequence | MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV |
UniProt | Q9Y271 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q9Y271 |
3D structure model | This predicted structure model is from GPCR-EXP Q9Y271. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL1798 |
IUPHAR | 269 |
DrugBank | BE0000705 |
Name | CHEMBL3808722 |
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Molecular formula | C22H19Cl2NO4 |
IUPAC name | 4,6-dichloro-3-[(E)-3-oxo-3-(4-phenylbutoxy)prop-1-enyl]-1H-indole-2-carboxylic acid |
Molecular weight | 432.297 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 2 |
XlogP | 6.1 |
Synonyms | BDBM50172357 |
Inchi Key | VGWGLUANXTUFPH-MDZDMXLPSA-N |
Inchi ID | InChI=1S/C22H19Cl2NO4/c23-15-12-17(24)20-16(21(22(27)28)25-18(20)13-15)9-10-19(26)29-11-5-4-8-14-6-2-1-3-7-14/h1-3,6-7,9-10,12-13,25H,4-5,8,11H2,(H,27,28)/b10-9+ |
PubChem CID | 127043409 |
ChEMBL | CHEMBL3808722 |
IUPHAR | N/A |
BindingDB | 50172357 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | <100000.0 nM | PMID26985325 | BindingDB,ChEMBL |
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