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GPCR

NameC-C chemokine receptor type 10
SpeciesHomo sapiens (Human)
GeneCCR10
SynonymCCR-10
CCR10
CC-CKR-10
G-protein coupled receptor 2
GPR-2
[ Show all ]
DiseaseInflammatory disease
Length362
Amino acid sequenceMGTEATEQVSWGHYSGDEEDAYSAEPLPELCYKADVQAFSRAFQPSVSLTVAALGLAGNGLVLATHLAARRAARSPTSAHLLQLALADLLLALTLPFAAAGALQGWSLGSATCRTISGLYSASFHAGFLFLACISADRYVAIARALPAGPRPSTPGRAHLVSVIVWLLSLLLALPALLFSQDGQREGQRRCRLIFPEGLTQTVKGASAVAQVALGFALPLGVMVACYALLGRTLLAARGPERRRALRVVVALVAAFVVLQLPYSLALLLDTADLLAARERSCPASKRKDVALLVTSGLALARCGLNPVLYAFLGLRFRQDLRRLLRGGSCPSGPQPRRGCPRRPRLSSCSAPTETHSLSWDN
UniProtP46092
Protein Data BankN/A
GPCR-HGmod modelP46092
3D structure modelThis predicted structure model is from GPCR-EXP P46092.
BioLiPN/A
Therapeutic Target DatabaseT71054
ChEMBLCHEMBL2321628
IUPHAR67
DrugBankN/A

Ligand

NameCHEMBL3731872
Molecular formulaC29H27ClF2N6O4S
IUPAC nameN-[7-(2-chloro-4-fluoro-5-methylanilino)-6-[4-(4-fluorophenyl)piperidine-1-carbonyl]pyrazolo[1,5-a]pyrimidin-3-yl]sulfonylcyclopropanecarboxamide
Molecular weight629.08
Hydrogen bond acceptor9
Hydrogen bond donor2
XlogP4.8
SynonymsSCHEMBL14471808
Inchi KeySXEQMNRMZZIGAB-UHFFFAOYSA-N
Inchi IDInChI=1S/C29H27ClF2N6O4S/c1-16-12-24(22(30)13-23(16)32)35-26-21(29(40)37-10-8-18(9-11-37)17-4-6-20(31)7-5-17)14-33-27-25(15-34-38(26)27)43(41,42)36-28(39)19-2-3-19/h4-7,12-15,18-19,35H,2-3,8-11H2,1H3,(H,36,39)
PubChem CID53377926
ChEMBLCHEMBL3731872
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition<100.0 %NoneChEMBL

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