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GPCR

NameC-C chemokine receptor type 10
SpeciesHomo sapiens (Human)
GeneCCR10
SynonymCCR-10
CCR10
CC-CKR-10
G-protein coupled receptor 2
GPR-2
[ Show all ]
DiseaseInflammatory disease
Length362
Amino acid sequenceMGTEATEQVSWGHYSGDEEDAYSAEPLPELCYKADVQAFSRAFQPSVSLTVAALGLAGNGLVLATHLAARRAARSPTSAHLLQLALADLLLALTLPFAAAGALQGWSLGSATCRTISGLYSASFHAGFLFLACISADRYVAIARALPAGPRPSTPGRAHLVSVIVWLLSLLLALPALLFSQDGQREGQRRCRLIFPEGLTQTVKGASAVAQVALGFALPLGVMVACYALLGRTLLAARGPERRRALRVVVALVAAFVVLQLPYSLALLLDTADLLAARERSCPASKRKDVALLVTSGLALARCGLNPVLYAFLGLRFRQDLRRLLRGGSCPSGPQPRRGCPRRPRLSSCSAPTETHSLSWDN
UniProtP46092
Protein Data BankN/A
GPCR-HGmod modelP46092
3D structure modelThis predicted structure model is from GPCR-EXP P46092.
BioLiPN/A
Therapeutic Target DatabaseT71054
ChEMBLCHEMBL2321628
IUPHAR67
DrugBankN/A

Ligand

NameCHEMBL3728893
Molecular formulaC29H29F2N7O4S
IUPAC name1-cyclopropyl-3-[7-(2-fluoro-5-methylanilino)-6-[4-(4-fluorophenyl)piperidine-1-carbonyl]pyrazolo[1,5-a]pyrimidin-3-yl]sulfonylurea
Molecular weight609.653
Hydrogen bond acceptor9
Hydrogen bond donor3
XlogP4.7
Synonyms7-(2-fluoro-5-methylphenylamino)-N-(cyclopropylcarbamoyl)-6-[4-(4-fluorophenyl)piperidine-1-carbonyl]pyrazolo[1,5-a]pyrimidine-3-sulfonamide
LYYATWSOAYDERR-UHFFFAOYSA-N
SCHEMBL14471886
Inchi KeyLYYATWSOAYDERR-UHFFFAOYSA-N
Inchi IDInChI=1S/C29H29F2N7O4S/c1-17-2-9-23(31)24(14-17)35-26-22(28(39)37-12-10-19(11-13-37)18-3-5-20(30)6-4-18)15-32-27-25(16-33-38(26)27)43(41,42)36-29(40)34-21-7-8-21/h2-6,9,14-16,19,21,35H,7-8,10-13H2,1H3,(H2,34,36,40)
PubChem CID53377814
ChEMBLCHEMBL3728893
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition<100.0 %NoneChEMBL

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