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Name | C-C chemokine receptor type 10 |
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Species | Homo sapiens (Human) |
Gene | CCR10 |
Synonym | CCR-10 CCR10 CC-CKR-10 G-protein coupled receptor 2 GPR-2 [ Show all ] |
Disease | Inflammatory disease |
Length | 362 |
Amino acid sequence | MGTEATEQVSWGHYSGDEEDAYSAEPLPELCYKADVQAFSRAFQPSVSLTVAALGLAGNGLVLATHLAARRAARSPTSAHLLQLALADLLLALTLPFAAAGALQGWSLGSATCRTISGLYSASFHAGFLFLACISADRYVAIARALPAGPRPSTPGRAHLVSVIVWLLSLLLALPALLFSQDGQREGQRRCRLIFPEGLTQTVKGASAVAQVALGFALPLGVMVACYALLGRTLLAARGPERRRALRVVVALVAAFVVLQLPYSLALLLDTADLLAARERSCPASKRKDVALLVTSGLALARCGLNPVLYAFLGLRFRQDLRRLLRGGSCPSGPQPRRGCPRRPRLSSCSAPTETHSLSWDN |
UniProt | P46092 |
Protein Data Bank | N/A |
GPCR-HGmod model | P46092 |
3D structure model | This predicted structure model is from GPCR-EXP P46092. |
BioLiP | N/A |
Therapeutic Target Database | T71054 |
ChEMBL | CHEMBL2321628 |
IUPHAR | 67 |
DrugBank | N/A |
Name | CHEMBL3730468 |
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Molecular formula | C28H29FN6O5S |
IUPAC name | N-[7-(4-fluoro-2-methylanilino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidin-3-yl]sulfonyl-2-methoxyacetamide |
Molecular weight | 580.635 |
Hydrogen bond acceptor | 9 |
Hydrogen bond donor | 2 |
XlogP | 3.5 |
Synonyms | SCHEMBL15915688 |
Inchi Key | KGCXJIYAQXLRMF-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C28H29FN6O5S/c1-18-14-21(29)8-9-23(18)32-26-22(28(37)34-12-10-20(11-13-34)19-6-4-3-5-7-19)15-30-27-24(16-31-35(26)27)41(38,39)33-25(36)17-40-2/h3-9,14-16,20,32H,10-13,17H2,1-2H3,(H,33,36) |
PubChem CID | 90313034 |
ChEMBL | CHEMBL3730468 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Inhibition | 94.2 % | None | ChEMBL |
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