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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Melanocortin receptor 5
Species	Mus musculus (Mouse)
Gene	Mc5r
Synonym	MC5 receptor MC5-R MC5R melanocortin receptor 5
Disease	N/A for non-human GPCRs
Length	325
Amino acid sequence	MNSSSTLTVLNLTLNASEDGILGSNVKNKSLACEEMGIAVEVFLTLGLVSLLENILVIGAIVKNKNLHSPMYFFVGSLAVADMLVSMSNAWETVTIYLLNNKHLVIADTFVRHIDNVFDSMICISVVASMCSLLAIAVDRYITIFYALRYHHIMTARRSGVIIACIWTFCISCGIVFIIYYESKYVIICLISMFFTMLFFMVSLYIHMFLLARNHVKRIAASPRYNSVRQRTSMKGAITLTMLLGIFIVCWSPFFLHLILMISCPQNVYCSCFMSYFNMYLILIMCNSVIDPLIYALRSQEMRRTFKEIVCCHGFRRPCRLLGGY
UniProt	P41149
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4489
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL272439
Molecular formula	C20H22ClN5O2
IUPAC name	2-[3-(1-benzyl-8-chloro-2,5-dioxo-3,4-dihydro-1,4-benzodiazepin-3-yl)propyl]guanidine
Molecular weight	399.879
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	1.7
Synonyms	BDBM50374124
Inchi Key	CWVXKDNUHVPLLR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H22ClN5O2/c21-14-8-9-15-17(11-14)26(12-13-5-2-1-3-6-13)19(28)16(25-18(15)27)7-4-10-24-20(22)23/h1-3,5-6,8-9,11,16H,4,7,10,12H2,(H,25,27)(H4,22,23,24)
PubChem CID	44457021
ChEMBL	CHEMBL272439
IUPHAR	N/A
BindingDB	50374124
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	17000.0 nM	PMID18271518	BindingDB,ChEMBL

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