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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Prostaglandin E2 receptor EP1 subtype
Species	Mus musculus (Mouse)
Gene	Ptger1
Synonym	EP1 prostanoid receptor EP1 receptor PGE receptor EP1 subtype PGE2 receptor EP1 subtype prostaglandin E receptor 1 (subtype EP1), 42kDa Prostanoid EP1 receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	405
Amino acid sequence	MSPCGLNLSLADEAATCATPRLPNTSVVLPTGDNGTSPALPIFSMTLGAVSNVLALALLAQVAGRMRRRRSAATFLLFVASLLAIDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTQPLIHAARVSVARARLALAVLAAMALAVALLPLVHVGRYELQYPGTWCFISLGPRGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRARWRRRRSRRFRKTAGPDDRRRWGSRGPRLASASSASSITSATATLRSSRGGGSARRVHAHDVEMVGQLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQAMLRQLLRLLPLRVSAKGGPTELGLTKSAWEASSLRSSRHSGFSHL
UniProt	P35375
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2181
IUPHAR	340
DrugBank	N/A

Ligand

Name	CHEMBL60555
Molecular formula	C19H32O5S
IUPAC name	5-[[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]methylsulfanyl]pentanoic acid
Molecular weight	372.52
Hydrogen bond acceptor	6
Hydrogen bond donor	3
XlogP	2.2
Synonyms	(11R,13E,15S)-9-Oxo-11,15-dihydroxy-6-thiaprosta-13-ene-1-oic acid BDBM50101862 5-[(S)-(R)-3-Hydroxy-2-((1R,2R)-3-hydroxy-oct-1-enyl)-5-oxo-cyclopentylmethylsulfanyl]-pentanoic acid
Inchi Key	CWUOLAUUOCLFCW-ZVBMZXMJSA-N
Inchi ID	InChI=1S/C19H32O5S/c1-2-3-4-7-14(20)9-10-15-16(18(22)12-17(15)21)13-25-11-6-5-8-19(23)24/h9-10,14-17,20-21H,2-8,11-13H2,1H3,(H,23,24)/b10-9+/t14-,15+,16+,17+/m0/s1
PubChem CID	44304334
ChEMBL	CHEMBL60555
IUPHAR	N/A
BindingDB	50101862
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	95.0 nM	PMID11454474	BindingDB,ChEMBL

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