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GPCR

NameC-C chemokine receptor type 10
SpeciesHomo sapiens (Human)
GeneCCR10
SynonymCCR-10
CCR10
CC-CKR-10
G-protein coupled receptor 2
GPR-2
[ Show all ]
DiseaseInflammatory disease
Length362
Amino acid sequenceMGTEATEQVSWGHYSGDEEDAYSAEPLPELCYKADVQAFSRAFQPSVSLTVAALGLAGNGLVLATHLAARRAARSPTSAHLLQLALADLLLALTLPFAAAGALQGWSLGSATCRTISGLYSASFHAGFLFLACISADRYVAIARALPAGPRPSTPGRAHLVSVIVWLLSLLLALPALLFSQDGQREGQRRCRLIFPEGLTQTVKGASAVAQVALGFALPLGVMVACYALLGRTLLAARGPERRRALRVVVALVAAFVVLQLPYSLALLLDTADLLAARERSCPASKRKDVALLVTSGLALARCGLNPVLYAFLGLRFRQDLRRLLRGGSCPSGPQPRRGCPRRPRLSSCSAPTETHSLSWDN
UniProtP46092
Protein Data BankN/A
GPCR-HGmod modelP46092
3D structure modelThis predicted structure model is from GPCR-EXP P46092.
BioLiPN/A
Therapeutic Target DatabaseT71054
ChEMBLCHEMBL2321628
IUPHAR67
DrugBankN/A

Ligand

NameCHEMBL3731775
Molecular formulaC30H29ClN6O5S
IUPAC nameN-[7-(4-chloro-2-methylanilino)-6-(spiro[1H-2-benzofuran-3,4'-piperidine]-1'-carbonyl)pyrazolo[1,5-a]pyrimidin-3-yl]sulfonylcyclopropanecarboxamide
Molecular weight621.109
Hydrogen bond acceptor8
Hydrogen bond donor2
XlogP3.7
SynonymsSCHEMBL15919251
Inchi KeyDQQQPEZKICVZRY-UHFFFAOYSA-N
Inchi IDInChI=1S/C30H29ClN6O5S/c1-18-14-21(31)8-9-24(18)34-26-22(15-32-27-25(16-33-37(26)27)43(40,41)35-28(38)19-6-7-19)29(39)36-12-10-30(11-13-36)23-5-3-2-4-20(23)17-42-30/h2-5,8-9,14-16,19,34H,6-7,10-13,17H2,1H3,(H,35,38)
PubChem CID90315919
ChEMBLCHEMBL3731775
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition<100.0 %NoneChEMBL

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