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Name | C-C chemokine receptor type 10 |
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Species | Homo sapiens (Human) |
Gene | CCR10 |
Synonym | CCR-10 CCR10 CC-CKR-10 G-protein coupled receptor 2 GPR-2 [ Show all ] |
Disease | Inflammatory disease |
Length | 362 |
Amino acid sequence | MGTEATEQVSWGHYSGDEEDAYSAEPLPELCYKADVQAFSRAFQPSVSLTVAALGLAGNGLVLATHLAARRAARSPTSAHLLQLALADLLLALTLPFAAAGALQGWSLGSATCRTISGLYSASFHAGFLFLACISADRYVAIARALPAGPRPSTPGRAHLVSVIVWLLSLLLALPALLFSQDGQREGQRRCRLIFPEGLTQTVKGASAVAQVALGFALPLGVMVACYALLGRTLLAARGPERRRALRVVVALVAAFVVLQLPYSLALLLDTADLLAARERSCPASKRKDVALLVTSGLALARCGLNPVLYAFLGLRFRQDLRRLLRGGSCPSGPQPRRGCPRRPRLSSCSAPTETHSLSWDN |
UniProt | P46092 |
Protein Data Bank | N/A |
GPCR-HGmod model | P46092 |
3D structure model | This predicted structure model is from GPCR-EXP P46092. |
BioLiP | N/A |
Therapeutic Target Database | T71054 |
ChEMBL | CHEMBL2321628 |
IUPHAR | 67 |
DrugBank | N/A |
Name | CHEMBL3731147 |
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Molecular formula | C30H32FN7O5S |
IUPAC name | N-[7-(4-fluoro-2-methylanilino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidin-3-yl]sulfonylmorpholine-4-carboxamide |
Molecular weight | 621.688 |
Hydrogen bond acceptor | 9 |
Hydrogen bond donor | 2 |
XlogP | 3.3 |
Synonyms | SCHEMBL15915539 |
Inchi Key | DEEOPOAONNSEDV-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C30H32FN7O5S/c1-20-17-23(31)7-8-25(20)34-27-24(29(39)36-11-9-22(10-12-36)21-5-3-2-4-6-21)18-32-28-26(19-33-38(27)28)44(41,42)35-30(40)37-13-15-43-16-14-37/h2-8,17-19,22,34H,9-16H2,1H3,(H,35,40) |
PubChem CID | 90312917 |
ChEMBL | CHEMBL3731147 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Inhibition | 85.9 % | None | ChEMBL |
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