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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled receptor 84
Species	Homo sapiens (Human)
Gene	GPR84
Synonym	GPCR4 GPR84 Inflammation-related G-protein coupled receptor EX33
Disease	N/A
Length	396
Amino acid sequence	MWNSSDANFSCYHESVLGYRYVAVSWGVVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIVLALVSTWVVGVASFAPLWPIYILVPVVCTCSFDRIRGRPYTTILMGIYFVLGLSSVGIFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGGPSEGISSEPVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFGKVTRMCFAVFLCFALSYIPFLLLNILDARVQAPRVVHMLAANLTWLNGCINPVLYAAMNRQFRQAYGSILKRGPRSFHRLH
UniProt	Q9NQS5
Protein Data Bank	N/A
GPCR-HGmod model	Q9NQS5
3D structure model	This predicted structure model is from GPCR-EXP Q9NQS5.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3714079
IUPHAR	120
DrugBank	N/A

Ligand

Name	CHEMBL3714952
Molecular formula	C24H23FN2O4
IUPAC name	9-[(4-fluorophenyl)methoxy]-2-(oxolan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one
Molecular weight	422.456
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	3.5
Synonyms	SCHEMBL15825809
Inchi Key	CEVGGJKJTXISSK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H23FN2O4/c25-18-5-3-16(4-6-18)14-30-19-7-8-21-17(12-19)9-10-27-22(21)13-23(26-24(27)28)31-15-20-2-1-11-29-20/h3-8,12-13,20H,1-2,9-11,14-15H2
PubChem CID	76684763
ChEMBL	CHEMBL3714952
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	100.0 nM	None	ChEMBL

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