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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled receptor 84
Species	Homo sapiens (Human)
Gene	GPR84
Synonym	GPCR4 GPR84 Inflammation-related G-protein coupled receptor EX33
Disease	N/A
Length	396
Amino acid sequence	MWNSSDANFSCYHESVLGYRYVAVSWGVVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIVLALVSTWVVGVASFAPLWPIYILVPVVCTCSFDRIRGRPYTTILMGIYFVLGLSSVGIFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGGPSEGISSEPVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFGKVTRMCFAVFLCFALSYIPFLLLNILDARVQAPRVVHMLAANLTWLNGCINPVLYAAMNRQFRQAYGSILKRGPRSFHRLH
UniProt	Q9NQS5
Protein Data Bank	N/A
GPCR-HGmod model	Q9NQS5
3D structure model	This predicted structure model is from GPCR-EXP Q9NQS5.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3714079
IUPHAR	120
DrugBank	N/A

Ligand

Name	CHEMBL3715514
Molecular formula	C22H24N2O4
IUPAC name	2-(1,4-dioxan-2-ylmethoxy)-9-pent-1-ynyl-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one
Molecular weight	380.444
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	2.8
Synonyms	SCHEMBL15050843
Inchi Key	BDMWQQBSFVLOPB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H24N2O4/c1-2-3-4-5-16-6-7-19-17(12-16)8-9-24-20(19)13-21(23-22(24)25)28-15-18-14-26-10-11-27-18/h6-7,12-13,18H,2-3,8-11,14-15H2,1H3
PubChem CID	89645316
ChEMBL	CHEMBL3715514
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	0.01 nM	None	ChEMBL

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