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Name | C-C chemokine receptor type 10 |
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Species | Homo sapiens (Human) |
Gene | CCR10 |
Synonym | CCR-10 CCR10 CC-CKR-10 G-protein coupled receptor 2 GPR-2 [ Show all ] |
Disease | Inflammatory disease |
Length | 362 |
Amino acid sequence | MGTEATEQVSWGHYSGDEEDAYSAEPLPELCYKADVQAFSRAFQPSVSLTVAALGLAGNGLVLATHLAARRAARSPTSAHLLQLALADLLLALTLPFAAAGALQGWSLGSATCRTISGLYSASFHAGFLFLACISADRYVAIARALPAGPRPSTPGRAHLVSVIVWLLSLLLALPALLFSQDGQREGQRRCRLIFPEGLTQTVKGASAVAQVALGFALPLGVMVACYALLGRTLLAARGPERRRALRVVVALVAAFVVLQLPYSLALLLDTADLLAARERSCPASKRKDVALLVTSGLALARCGLNPVLYAFLGLRFRQDLRRLLRGGSCPSGPQPRRGCPRRPRLSSCSAPTETHSLSWDN |
UniProt | P46092 |
Protein Data Bank | N/A |
GPCR-HGmod model | P46092 |
3D structure model | This predicted structure model is from GPCR-EXP P46092. |
BioLiP | N/A |
Therapeutic Target Database | T71054 |
ChEMBL | CHEMBL2321628 |
IUPHAR | 67 |
DrugBank | N/A |
Name | CHEMBL3730003 |
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Molecular formula | C28H26ClFN6O4S |
IUPAC name | N-[7-(2-chloroanilino)-6-[4-(4-fluorophenyl)piperidine-1-carbonyl]pyrazolo[1,5-a]pyrimidin-3-yl]sulfonylcyclopropanecarboxamide |
Molecular weight | 597.062 |
Hydrogen bond acceptor | 8 |
Hydrogen bond donor | 2 |
XlogP | 4.4 |
Synonyms | SCHEMBL14471810 |
Inchi Key | AZNYZHVZPJRLSK-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C28H26ClFN6O4S/c29-22-3-1-2-4-23(22)33-25-21(28(38)35-13-11-18(12-14-35)17-7-9-20(30)10-8-17)15-31-26-24(16-32-36(25)26)41(39,40)34-27(37)19-5-6-19/h1-4,7-10,15-16,18-19,33H,5-6,11-14H2,(H,34,37) |
PubChem CID | 71178970 |
ChEMBL | CHEMBL3730003 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Inhibition | 80.6 % | None | ChEMBL |
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