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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	AC1NESFS
Molecular formula	C15H19N5O4S
IUPAC name	1,3,7-trimethyl-5-(2-morpholin-4-yl-2-oxoethyl)sulfanylpyrimido[4,5-d]pyrimidine-2,4-dione
Molecular weight	365.408
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	-0.2
Synonyms	SR-01000132150-1 HMS2760I06 1,3,7-trimethyl-5-((2-morpholino-2-oxoethyl)thio)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione SMR000319998 CHEMBL1366449 MLS000420134 1,3,7-trimethyl-5-(2-morpholin-4-yl-2-oxoethyl)sulfanylpyrimido[4,5-d]pyrimidine-2,4-dione SR-01000132150 AKOS024679436 F0654-0015 SCHEMBL1278838 [ Show all ]
Inchi Key	VLBUSVPJVTYFJB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H19N5O4S/c1-9-16-12-11(14(22)19(3)15(23)18(12)2)13(17-9)25-8-10(21)20-4-6-24-7-5-20/h4-8H2,1-3H3
PubChem CID	4622405
ChEMBL	CHEMBL1366449
IUPHAR	N/A
BindingDB	211238
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1006.0 nM	N/A	BindingDB
IC50	1006.0 nM	None	ChEMBL

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