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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1615504
Molecular formula	C23H29NO5S
IUPAC name	4-[[(3-methoxyphenyl)methyl-(4-methylphenyl)sulfonylamino]methyl]cyclohexane-1-carboxylic acid
Molecular weight	431.547
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	3.9
Synonyms	US9247759, 5-128 CHEMBL3909546 BDBM211181
Inchi Key	UMYOESGWZRLFFO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H29NO5S/c1-17-6-12-22(13-7-17)30(27,28)24(16-19-4-3-5-21(14-19)29-2)15-18-8-10-20(11-9-18)23(25)26/h3-7,12-14,18,20H,8-11,15-16H2,1-2H3,(H,25,26)
PubChem CID	57422404
ChEMBL	CHEMBL3909546
IUPHAR	N/A
BindingDB	211181
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	36.0 nM	N/A	BindingDB
IC50	36.0 nM	None	ChEMBL

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