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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1279561
Molecular formula	C24H25NO7S
IUPAC name	4-[benzyl-[(2,4,6-trimethoxyphenyl)methyl]sulfamoyl]benzoic acid
Molecular weight	471.524
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	3.5
Synonyms	TWXMDQCPJHAYOY-UHFFFAOYSA-N 4-(N-benzyl-N-(2,4,6-trimethoxybenzyl)sulfamoyl)benzoic acid CHEMBL3913926 US9247759, 5-15 BDBM211094
Inchi Key	TWXMDQCPJHAYOY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H25NO7S/c1-30-19-13-22(31-2)21(23(14-19)32-3)16-25(15-17-7-5-4-6-8-17)33(28,29)20-11-9-18(10-12-20)24(26)27/h4-14H,15-16H2,1-3H3,(H,26,27)
PubChem CID	57422337
ChEMBL	CHEMBL3913926
IUPHAR	N/A
BindingDB	211094
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	10760.0 nM	N/A	BindingDB
IC50	10760.0 nM	None	ChEMBL

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