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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1615022
Molecular formula	C22H21NO5S
IUPAC name	4-[[benzenesulfonyl-[(4-methoxyphenyl)methyl]amino]methyl]benzoic acid
Molecular weight	411.472
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	3.6
Synonyms	US9247759, 5-102 CHEMBL3978325 US9247759, 5-154 BDBM211160
Inchi Key	QHHLOQNDAKGJKY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H21NO5S/c1-28-20-13-9-18(10-14-20)16-23(29(26,27)21-5-3-2-4-6-21)15-17-7-11-19(12-8-17)22(24)25/h2-14H,15-16H2,1H3,(H,24,25)
PubChem CID	57422393
ChEMBL	CHEMBL3978325
IUPHAR	N/A
BindingDB	211160
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	2219.0 nM	N/A	BindingDB
IC50	2219.0 nM	None	ChEMBL

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