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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	Oprea1_395930
Molecular formula	C22H26FNO5S
IUPAC name	4-[[(4-fluorophenyl)methyl-(4-methoxyphenyl)sulfonylamino]methyl]cyclohexane-1-carboxylic acid
Molecular weight	435.51
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	3.6
Synonyms	SCHEMBL1615055 CHEMBL3905445 US9247759, 5-123 BDBM211176
Inchi Key	PQPILKNDFPNCSN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H26FNO5S/c1-29-20-10-12-21(13-11-20)30(27,28)24(15-17-4-8-19(23)9-5-17)14-16-2-6-18(7-3-16)22(25)26/h4-5,8-13,16,18H,2-3,6-7,14-15H2,1H3,(H,25,26)
PubChem CID	23827358
ChEMBL	CHEMBL3905445
IUPHAR	N/A
BindingDB	211176
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	92.0 nM	None	ChEMBL
IC50	92.0 nM	N/A	BindingDB

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