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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1616132
Molecular formula	C21H25FN2O4S
IUPAC name	4-[[(4-aminophenyl)sulfonyl-[(4-fluorophenyl)methyl]amino]methyl]cyclohexane-1-carboxylic acid
Molecular weight	420.499
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	3.0
Synonyms	BDBM211178 US9247759, 5-125 CHEMBL3907800
Inchi Key	OSSDZRCJJNEHIQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H25FN2O4S/c22-18-7-3-16(4-8-18)14-24(13-15-1-5-17(6-2-15)21(25)26)29(27,28)20-11-9-19(23)10-12-20/h3-4,7-12,15,17H,1-2,5-6,13-14,23H2,(H,25,26)
PubChem CID	57944937
ChEMBL	CHEMBL3907800
IUPHAR	N/A
BindingDB	211178
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1651.0 nM	None	ChEMBL
IC50	1651.0 nM	N/A	BindingDB

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