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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1279684
Molecular formula	C25H32N2O2S
IUPAC name	4-[[(4-ethylphenyl)methyl-[(2-methylphenyl)carbamothioyl]amino]methyl]cyclohexane-1-carboxylic acid
Molecular weight	424.603
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	5.4
Synonyms	US9247759, 5-113 CHEMBL3902385 BDBM211167
Inchi Key	MCFYRTZREACIMF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H32N2O2S/c1-3-19-8-10-20(11-9-19)16-27(17-21-12-14-22(15-13-21)24(28)29)25(30)26-23-7-5-4-6-18(23)2/h4-11,21-22H,3,12-17H2,1-2H3,(H,26,30)(H,28,29)
PubChem CID	57422401
ChEMBL	CHEMBL3902385
IUPHAR	N/A
BindingDB	211167
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	5018.0 nM	None	ChEMBL
IC50	5018.0 nM	N/A	BindingDB

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