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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1279497
Molecular formula	C23H23NO4S
IUPAC name	4-[benzyl-[(4-ethylphenyl)methyl]sulfamoyl]benzoic acid
Molecular weight	409.5
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	4.4
Synonyms	US9247759, 143 CHEMBL3984415 US9247759, 5-85 BDBM211149
Inchi Key	LQWYPRJEEQNGHT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H23NO4S/c1-2-18-8-10-20(11-9-18)17-24(16-19-6-4-3-5-7-19)29(27,28)22-14-12-21(13-15-22)23(25)26/h3-15H,2,16-17H2,1H3,(H,25,26)
PubChem CID	57422376
ChEMBL	CHEMBL3984415
IUPHAR	N/A
BindingDB	211149
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	8580.0 nM	None	ChEMBL
IC50	8580.0 nM	N/A	BindingDB

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