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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1279764
Molecular formula	C22H21NO6S
IUPAC name	4-[[(4-hydroxyphenyl)sulfonyl-[(3-methoxyphenyl)methyl]amino]methyl]benzoic acid
Molecular weight	427.471
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	3.2
Synonyms	US9247759, 5-43 CHEMBL3901989 BDBM211119
Inchi Key	LMGGVTVXSSGCMW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H21NO6S/c1-29-20-4-2-3-17(13-20)15-23(14-16-5-7-18(8-6-16)22(25)26)30(27,28)21-11-9-19(24)10-12-21/h2-13,24H,14-15H2,1H3,(H,25,26)
PubChem CID	25207288
ChEMBL	CHEMBL3901989
IUPHAR	N/A
BindingDB	211119
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	188.0 nM	N/A	BindingDB
IC50	188.0 nM	None	ChEMBL

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