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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1279013
Molecular formula	C22H19NO6S
IUPAC name	4-[1,3-benzodioxol-5-ylmethyl(benzyl)sulfamoyl]benzoic acid
Molecular weight	425.455
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	3.4
Synonyms	US9247759, 5-148 CHEMBL3907115 US9247759, 5-93 BDBM211154
Inchi Key	HGBARHIQMAAKKA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H19NO6S/c24-22(25)18-7-9-19(10-8-18)30(26,27)23(13-16-4-2-1-3-5-16)14-17-6-11-20-21(12-17)29-15-28-20/h1-12H,13-15H2,(H,24,25)
PubChem CID	57422384
ChEMBL	CHEMBL3907115
IUPHAR	N/A
BindingDB	211154
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	2167.0 nM	N/A	BindingDB
IC50	2167.0 nM	None	ChEMBL

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