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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	4-[((4-methoxybenzyl){[(2-methoxyphenyl)amino]carbonothioyl}amino)methyl]cyclohexanecarboxylic acid
Molecular formula	C24H30N2O4S
IUPAC name	4-[[(2-methoxyphenyl)carbamothioyl-[(4-methoxyphenyl)methyl]amino]methyl]cyclohexane-1-carboxylic acid
Molecular weight	442.574
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	4.1
Synonyms	US9247759, 5-112 CHEMBL1326627 MolPort-007-929-138 SR-01000582766 BDBM211166 ZINC15962023 HMS2700L13 SCHEMBL1863716 SR-01000582766-1 MLS000673578 SMR000314819 AKOS001587252 [ Show all ]
Inchi Key	GWTFPMQVFXBOOD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H30N2O4S/c1-29-20-13-9-18(10-14-20)16-26(15-17-7-11-19(12-8-17)23(27)28)24(31)25-21-5-3-4-6-22(21)30-2/h3-6,9-10,13-14,17,19H,7-8,11-12,15-16H2,1-2H3,(H,25,31)(H,27,28)
PubChem CID	16189605
ChEMBL	CHEMBL1326627
IUPHAR	N/A
BindingDB	211166
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	8852.0 nM	None	ChEMBL
IC50	8852.0 nM	N/A	BindingDB

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