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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	AC1NDBVX
Molecular formula	C24H29ClN2O2S
IUPAC name	4-[[(4-chloro-3-methylphenyl)carbamothioyl-[(2-methylphenyl)methyl]amino]methyl]cyclohexane-1-carboxylic acid
Molecular weight	445.018
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	5.6
Synonyms	4-[[(4-chloro-3-methylphenyl)carbamothioyl-[(2-methylphenyl)methyl]amino]methyl]cyclohexane-1-carboxylic acid SCHEMBL1650341 AKOS002107090 US9247759, 5-114 CHEMBL3980678 4-{[{[(4-chloro-3-methylphenyl)amino]carbonothioyl}(2-methylbenzyl)amino]methyl}cyclohexanecarboxylic acid SR-01000582978 BDBM211168 ZINC3036358 MolPort-007-929-333 SR-01000582978-1 [ Show all ]
Inchi Key	FZGLHZIPDFVDKB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H29ClN2O2S/c1-16-5-3-4-6-20(16)15-27(14-18-7-9-19(10-8-18)23(28)29)24(30)26-21-11-12-22(25)17(2)13-21/h3-6,11-13,18-19H,7-10,14-15H2,1-2H3,(H,26,30)(H,28,29)
PubChem CID	4547698
ChEMBL	CHEMBL3980678
IUPHAR	N/A
BindingDB	211168
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	4872.0 nM	None	ChEMBL
IC50	4872.0 nM	N/A	BindingDB

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