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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1279380
Molecular formula	C22H20FNO5S
IUPAC name	4-[(4-fluorophenyl)methyl-[(4-methoxyphenyl)methyl]sulfamoyl]benzoic acid
Molecular weight	429.462
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	3.7
Synonyms	CHEMBL3930424 US9247759, 5-10 BDBM211089 DFSLJMTUTPQCHL-UHFFFAOYSA-N US9247759, 5-69 4-(N-(4-fluorobenzyl)-N-(4-methoxybenzyl)sulfamoyl)benzoic acid [ Show all ]
Inchi Key	DFSLJMTUTPQCHL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H20FNO5S/c1-29-20-10-4-17(5-11-20)15-24(14-16-2-8-19(23)9-3-16)30(27,28)21-12-6-18(7-13-21)22(25)26/h2-13H,14-15H2,1H3,(H,25,26)
PubChem CID	25205359
ChEMBL	CHEMBL3930424
IUPHAR	N/A
BindingDB	211089
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1970.0 nM	None	ChEMBL
IC50	1970.0 nM	N/A	BindingDB
IC50	8283.0 nM	N/A	BindingDB
IC50	8283.0 nM	None	ChEMBL

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